Department of Neurology, Seoul Medical Center, Seoul, Korea.
Am J Alzheimers Dis Other Demen. 2013 Mar;28(2):120-5. doi: 10.1177/1533317512473193. Epub 2013 Jan 9.
Oxidative stress is suggested to play a major role in the pathogenesis of Alzheimer's disease (AD). Among the antioxidants, vitamin C has been regarded as the most important one in neural tissue. It also decreases β-amyloid generation and acetylcholinesterase activity and prevents endothelial dysfunction by regulating nitric oxide, a newly discovered factor in the pathogenesis and progression of AD. However, clinical trials using antioxidants, including vitamin C, in patients with AD yielded equivocal results. The current article discusses the relevance of vitamin C in the cellular and molecular pathogenesis of AD and explores its therapeutic potential against this neurodegenerative disorder.
氧化应激被认为在阿尔茨海默病（AD）的发病机制中起主要作用。在抗氧化剂中，维生素 C 一直被认为是神经组织中最重要的抗氧化剂。它还通过调节一氧化氮（AD 发病机制和进展中的一个新发现因素）来减少β-淀粉样蛋白的生成和乙酰胆碱酯酶的活性，并预防内皮功能障碍。然而，在 AD 患者中使用抗氧化剂（包括维生素 C）的临床试验结果却存在争议。本文讨论了维生素 C 在 AD 的细胞和分子发病机制中的相关性，并探讨了其治疗这种神经退行性疾病的潜力。
