Hallman J, Sakurai E, Oreland L
Department of Psychiatry, University of Uppsala, Sweden.
Acta Psychiatr Scand. 1990 Jan;81(1):73-7. doi: 10.1111/j.1600-0447.1990.tb06452.x.
Platelet monoamine oxidase (MAO) activity, serotonin uptake rate and serotonin efflux rate have all been suggested to be markers for central serotonergic mechanisms. Platelet MAO activity is associated with certain personality traits, with low activity linked to traits such as impulsiveness, sensation-seeking and avoidance of monotony, all possible expressions of low central serotonergic activity. Low platelet serotonin uptake rate has been connected to unipolar depression and the rate of efflux, in the presence of the ATP uncoupler CCP, higher in bipolar depressives than in controls. Platelet MAO was found to be lower in 16 consecutive female inpatients fulfilling the DSM-III criteria for bulimia nervosa than in 12 female controls. Rates of serotonin uptake and efflux in the presence of CCP were, on the other hand, similar to the controls. In the controls there were no correlations between platelet MAO activity and any of the other parameters estimated. Vmax for the platelet uptake of serotonin correlated positively with the Km for the uptake, but not with any other parameter. The uninfluenced rate of efflux of serotonin correlated positively with the efflux in the presence of the ATP uncoupler CCP.
血小板单胺氧化酶（MAO）活性、血清素摄取率和血清素流出率均被认为是中枢血清素能机制的标志物。血小板MAO活性与某些人格特质相关，活性低与冲动、寻求刺激和避免单调等特质有关，这些都是中枢血清素能活性低的可能表现。血小板血清素摄取率低与单相抑郁症有关，而在ATP解偶联剂CCP存在的情况下，双相抑郁症患者的血清素流出率高于对照组。研究发现，连续16名符合DSM-III神经性贪食症标准的女性住院患者的血小板MAO低于12名女性对照组。另一方面，在CCP存在的情况下，血清素摄取率和流出率与对照组相似。在对照组中，血小板MAO活性与其他任何估计参数之间均无相关性。血小板摄取血清素的Vmax与摄取的Km呈正相关，但与其他任何参数均无相关性。血清素不受影响的流出率与ATP解偶联剂CCP存在时的流出率呈正相关。
