Gruber W C, Taber L H, Glezen W P, Clover R D, Abell T D, Demmler R W, Couch R B
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Tex.
Am J Dis Child. 1990 May;144(5):595-600. doi: 10.1001/archpedi.1990.02150290089035.
In 1985, we enrolled 189 school-age children by family in a double-blind study to determine protection against influenza by a single dose of cold-recombinant bivalent A vaccine or commercial trivalent inactivated vaccine compared with placebo. All children in school or day care, 3 to 18 years of age, in an enrolled family received the same preparation. Following vaccination, 60% and 21% of cold-recombinant bivalent A vaccine recipients and 73% and 83% of trivalent inactivated vaccine recipients demonstrated fourfold or greater response in hemagglutination-inhibition antibody titer to A/H1N1 and A/H3N2, respectively. Sixty-seven percent of all trivalent inactivated vaccine recipients demonstrated a fourfold or greater serologic response to H1N1, H3N2, and influenza B following a single dose of vaccine. During the 1985-1986 influenza B/Ann Arbor epidemic, heterotypic protection afforded by the influenza B/USSR component of trivalent inactivated vaccine was 62% compared with placebo. A single dose of trivalent inactivated vaccine protected school-age children, 6 to 19 years of age, from influenza B infection; the rate of protection was 64% against infection and 73% against febrile illness.
1985年，我们通过家庭招募了189名学龄儿童参与一项双盲研究，以确定单剂量冷重组二价A疫苗或市售三价灭活疫苗与安慰剂相比预防流感的效果。参与研究的家庭中所有3至18岁在上学或日托机构的儿童都接受相同的制剂。接种疫苗后，冷重组二价A疫苗接种者中分别有60%和21%、三价灭活疫苗接种者中分别有73%和83%对A/H1N1和A/H3N2的血凝抑制抗体效价出现四倍或更高的增长。所有三价灭活疫苗接种者中有67%在接种单剂量疫苗后对H1N1、H3N2和乙型流感病毒出现四倍或更高的血清学反应。在1985 - 1986年乙型流感/安阿伯疫情期间，与安慰剂相比，三价灭活疫苗中乙型流感/苏联组分提供的异型保护率为62%。单剂量三价灭活疫苗可保护6至19岁的学龄儿童免受乙型流感感染；预防感染的保护率为64%，预防发热疾病的保护率为73%。
