Leonardy N J, Rupani M, Dent G, Klintworth G K
Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Am J Ophthalmol. 1990 Apr 15;109(4):436-44. doi: 10.1016/s0002-9394(14)74610-0.
To explain the marked variation in the reported incidence of how often leukemic cells infiltrate the eye in fatal cases of leukemia, we tested the hypothesis that ocular leukemic infiltration is related to the peripheral leukocyte count during the final hours of life. We reviewed tissue sections, as well as autopsy and clinical records, from 135 patients who had fatal leukemia and had their eyes examined after death at Duke University Medical Center. Infiltrates of leukemic cells were found in the eyes of 42 of 135 patients (31.1%), with the choroid being the most frequently involved site. We detected a significant positive correlation between the ocular leukemic infiltration and an agonal leukocyte count as well as the severity of systemic disease. Differences in the agonal circulating leukocyte count may partly explain variations in the incidence of leukemic infiltrates in different postmortem studies.
为了解释白血病致死病例中白血病细胞浸润眼部的报道发病率存在显著差异的原因，我们检验了这样一个假设：眼部白血病浸润与生命最后数小时的外周白细胞计数有关。我们回顾了135例致命性白血病患者的组织切片、尸检及临床记录，这些患者在杜克大学医学中心死亡后接受了眼部检查。135例患者中有42例（31.1%）的眼睛发现有白血病细胞浸润，脉络膜是最常受累的部位。我们检测到眼部白血病浸润与临终白细胞计数以及全身疾病严重程度之间存在显著正相关。临终循环白细胞计数的差异可能部分解释了不同尸检研究中白血病浸润发病率的差异。
