Mathison R, Befus A D, Davison J S
Department of Medical Physiology, University of Calgary, Alberta, Canada.
Am J Physiol. 1990 Apr;258(4 Pt 2):H1126-31. doi: 10.1152/ajpheart.1990.258.4.H1126.
Thirty days after infection with the parasite Nippostrongylus brasiliensis, microcirculatory changes associated with worm allergen-induced anaphylactic shock in pentobarbital-anesthetized rats were studied. Allergen challenge decreased heart rate, mean arterial blood pressure, and cardiac output (CO) for 60 min, although CO increased markedly by 240 min. Blood flow (ml.min-1.g wet tissue-1) was reduced to most tissues, with the exception of the kidneys, hepatic arterial, heart, and brain, for 60 min. Depressed flow to the adrenals and enhanced flow to the kidneys, trachea, stomach, and mesentery were observed at 240 min. The percent distribution of cardiac output per gram wet tissue (%CO/g) increased initially to the kidneys, heart, liver, and cervical spinal cord, decreased to the spleen and cecum, and remained unchanged to other gastrointestinal tissues. The %CO/g to most tissues returned to normal by 60 min but decreased to the adrenals at 240 min. The intestine is an important organ affected by anaphylaxis in the rat, and the liver may participate in alleviating anaphylaxis.
在用巴西日圆线虫寄生虫感染30天后，研究了戊巴比妥麻醉大鼠中与蠕虫过敏原诱导的过敏性休克相关的微循环变化。过敏原激发使心率、平均动脉血压和心输出量（CO）在60分钟内下降，尽管在240分钟时CO显著增加。除肾脏、肝动脉、心脏和脑外，大多数组织的血流量（毫升·分钟⁻¹·克湿组织⁻¹）在60分钟内减少。在240分钟时观察到肾上腺血流量降低，而肾脏、气管、胃和肠系膜的血流量增加。每克湿组织的心输出量百分比分布（%CO/g）最初增加到肾脏、心脏、肝脏和颈脊髓，然后减少到脾脏和盲肠，而其他胃肠道组织保持不变。大多数组织的%CO/g在60分钟时恢复正常，但在240分钟时降低到肾上腺。肠道是大鼠中受过敏反应影响的重要器官，肝脏可能参与缓解过敏反应。
