Kapin M A, Ferguson J L
Am J Physiol. 1985 Aug;249(2 Pt 2):H430-7. doi: 10.1152/ajpheart.1985.249.2.H430.
Microspheres were employed to measure the cardiac output (CO), percent distribution of CO (%CO), and blood flow (BF) to various tissues in the dog during anaphylactic shock. Five minutes after challenge there was a 66 and 83% drop from control for mean arterial pressure and CO, respectively. Arterial glucose and lactic acid rose 62 and 537%, respectively. Furthermore, there was a narrowing of the systemic arteriovenous difference for PO2 and a widening of the venoarterial difference for PCO2. Pressure compensation toward control values began 5 min postchallenge and continued through 180 min. Circulatory perturbations during severe hypotension (less than mmHg) included depressed %CO and BF to the pancreas and spleen and elevated %CO to the brain and adrenals. Cerebral and adrenal BF remained unchanged at this period. BF to the kidneys, liver (hepatic artery), and gastrointestinal tract dropped markedly as a function of increased peripheral resistance and decreased CO. As cardiac performance improved, blood flow to the pancreas, spleen, liver, diaphragm, and gastrointestinal tissues returned toward control but was elevated to the adrenals and decreased to the brain.
在过敏性休克期间，使用微球测量犬的心输出量（CO）、心输出量百分比分布（%CO）以及各组织的血流量（BF）。激发后5分钟，平均动脉压和心输出量分别比对照下降了66%和83%。动脉血糖和乳酸分别升高了62%和537%。此外，PO2的体循环动静脉差值变窄，PCO2的静脉动脉差值变宽。激发后5分钟开始向对照值进行压力代偿，并持续到180分钟。严重低血压（低于mmHg）期间的循环紊乱包括胰腺和脾脏的%CO和BF降低，以及大脑和肾上腺的%CO升高。在此期间，脑和肾上腺的BF保持不变。随着外周阻力增加和心输出量减少，肾脏、肝脏（肝动脉）和胃肠道的BF显著下降。随着心脏功能改善，胰腺、脾脏、肝脏、膈肌和胃肠道组织的血流量恢复到对照水平，但肾上腺的血流量升高，大脑的血流量降低。
