Deramoudt V, Gaudon M, Malledant Y, Chatellier A, Saint-Marc C, Lecallonnec A
Département d'Anesthésie-Réanimation, Hôpital Pontchaillou, Rennes.
Ann Fr Anesth Reanim. 1990;9(1):1-5. doi: 10.1016/s0750-7658(05)80028-0.
Propofol was assessed for eye surgery in 20 children. ASA group I or II, 2-14 year-old, randomly assigned to 2 equal groups. Premedication, analgesia and muscle paralysis were similar in both groups. Group P patients were given an induction dose of 4 mg.kg-1 propofol, followed by an infusion of 15 mg.kg-1.h-1 for the first half hour, and then 10 mg.kg-1.h-1 to maintain anaesthesia. Group C patients were given 10 mg.kg-1 thiopentone for induction and halothane for maintenance. The quality of anaesthesia was assessed by monitoring adverse effects, heart rate, blood pressure, the length of anaesthesia, the delay of the first spontaneous breath and eye opening, and extubation. Intraocular pressure was measured before and 3 min after intubation, and 5 min after extubation. The quality of anaesthetic induction and maintenance were very similar in both groups. Pain occurred more frequently at the injection site with propofol (p less than 0.01). Children in group P recovered more quickly, and extubation was possible much earlier in this group (p less than 0.05). However, restlessness was significantly more frequent in group P (n = 9) than in group C (n = 1) (p less than 0.01). Systolic, diastolic blood pressure and heart rate were significantly lower in group P (p less than 0.05; 0.001; 0.001 respectively). No significant decrease in intraocular pressure in both groups was observed. The use of propofol for eye surgery in children is acceptable, despite some restlessness during recovery.
对20名儿童进行了丙泊酚用于眼科手术的评估。年龄在2至14岁的ASA I级或II级儿童，随机分为两组。两组的术前用药、镇痛和肌肉松弛情况相似。P组患者给予4mg·kg⁻¹的丙泊酚诱导剂量，随后在前半小时以15mg·kg⁻¹·h⁻¹的速度输注，然后以10mg·kg⁻¹·h⁻¹维持麻醉。C组患者给予10mg·kg⁻¹的硫喷妥钠诱导并使用氟烷维持麻醉。通过监测不良反应、心率、血压、麻醉时间、首次自主呼吸和睁眼延迟以及拔管情况来评估麻醉质量。在插管前、插管后3分钟和拔管后5分钟测量眼压。两组的麻醉诱导和维持质量非常相似。丙泊酚注射部位疼痛发生率更高（p<0.01）。P组儿童恢复更快，且该组更早可以拔管（p<0.05）。然而，P组（n = 9）躁动明显比C组（n = 1）更频繁（p<0.01）。P组的收缩压、舒张压和心率显著更低（分别为p<0.05；0.001；0.001）。两组均未观察到眼压有显著下降。尽管恢复过程中有一些躁动，但丙泊酚用于儿童眼科手术是可以接受的。
