Siffredi Vanessa, Anderson Vicki, Leventer Richard J, Spencer-Smith Megan M
Murdoch Childrens Research Institute, Melbourne, Australia.
Dev Neuropsychol. 2013;38(1):36-57. doi: 10.1080/87565641.2012.721421.
Developmental absence (agenesis) of the corpus callosum (AgCC) is a common brain malformation that presents in isolation or in association with other conditions. Variability in aspects of neuropsychological functioning has been reported in small samples of individuals. This study aimed to systematically review the literature to characterize the profile and severity of cognitive impairments in individuals with AgCC across development. A mean general intellectual ability was calculated and neuropsychological functioning was qualitatively examined. We discuss methodological limitations of the literature, inherent heterogeneity of the causes and comorbidities of AgCC, and the developmental aspect of AgCC in opposition to "split-brain patients."
胼胝体发育不全（AgCC）是一种常见的脑畸形，可单独出现或与其他病症相关。在小样本个体中已报告了神经心理功能方面的变异性。本研究旨在系统回顾文献，以描述AgCC个体在整个发育过程中认知障碍的特征和严重程度。计算了平均一般智力能力，并对神经心理功能进行了定性检查。我们讨论了文献的方法学局限性、AgCC病因和合并症的内在异质性，以及与“裂脑患者”相对的AgCC的发育方面。
