Department of Psychology, University of Houston.
Department of Pediatric Surgery, University of Texas Health Science Center at Houston.
Neuropsychology. 2024 Nov;38(8):687-698. doi: 10.1037/neu0000915.
Maldevelopment of the posterior corpus callosum is common in spina bifida myelomeningocele (SBM) due to hydrocephalus-related hypoplasia and congenital partial hypogenesis. This study examined the relations of macro- and microstructural integrity of the interhemispheric temporal tract in SBM and auditory interhemispheric transfer using consonant-vowel dichotic listening.
We collected ₁-weighted and diffusion tensor imaging data from 46 individuals with SBM and 15 typically developing individuals. Probabilistic tractography was used to isolate the interhemispheric white matter connecting auditory processing regions in both hemispheres. Interhemispheric transfer was assessed with a dichotic listening task.
Although the typically developing group and the group with SBM showed the normative right-ear advantage, fewer participants showed a right-ear advantage in the group with SBM. The absence of the right-ear advantage was largely in the subgroup with hypogenesis of the splenium or severe posterior hypoplasia. Sex, anterior commissure cross-sectional area, and number of shunt pathways visible on magnetic resonance imaging predicted right-ear superiority.
Interhemispheric transfer is disrupted in individuals with SBM and hypogenesis or severe hypoplasia of the posterior corpus callosum. Preservation of interhemispheric transfer is related to expected connections through the posterior corpus callosum and possibly compensatory pathways in the anterior commissure. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
由于脑积水相关的发育不良和先天性部分发育不全，脊髓脊膜膨出（SBM）患者的胼胝体后部常发育不良。本研究使用辅音-元音双听测试检查了 SBM 患者大脑半球间颞叶束的宏观和微观结构完整性与听觉大脑半球间转移之间的关系。
我们从 46 名 SBM 患者和 15 名典型发育个体中收集了 T₁ 加权和弥散张量成像数据。概率追踪用于分离连接两个半球听觉处理区域的大脑半球间白质。使用双听任务评估大脑半球间的转移。
尽管典型发育组和 SBM 组均表现出正常的右耳优势，但 SBM 组中较少的参与者表现出右耳优势。右耳优势的缺失主要发生在胼胝体体部发育不全或后部严重发育不全亚组中。性别、前连合横截面积以及磁共振成像上可见的分流途径数量可预测右耳优势。
大脑半球间转移在胼胝体发育不全或后部严重发育不良的 SBM 患者中受到干扰。大脑半球间转移的保留与通过胼胝体的预期连接以及前连合的可能代偿途径有关。
