Grupo de Fotônica e Fluidos Complexos, Instituto de Física, Universidade Federal de Alagoas, 57072-970 Maceió, Alagoas, Brazil.
ACS Nano. 2013 Feb 26;7(2):1188-99. doi: 10.1021/nn304373q. Epub 2013 Jan 24.
In this work, we report the multifunctional character of neodymium-doped LaF₃ core/shell nanoparticles. Because of the spectral overlap of the neodymium emission bands with the transparency windows of human tissues, these nanoparticles emerge as relevant subtissue optical probes. For neodymium contents optimizing the luminescence brightness of Nd³⁺:LaF₃ nanoparticles, subtissue penetration depths of several millimeters have been demonstrated. At the same time, it has been found that the infrared emission bands of Nd³⁺:LaF₃ nanoparticles show a remarkable thermal sensitivity, so that they can be advantageously used as luminescent nanothermometers for subtissue thermal sensing. This possibility has been demonstrated in this work: Nd³⁺:LaF₃ nanoparticles have been used to provide optical control over subtissue temperature in a single-beam plasmonic-mediated heating experiment. In this experiment, gold nanorods are used as nanoheaters while thermal reading is performed by the Nd³⁺:LaF₃ nanoparticles. The possibility of a real single-beam-controlled subtissue hyperthermia process is, therefore, pointed out.
在这项工作中，我们报告了掺钕氟化镧核/壳纳米粒子的多功能特性。由于钕的发射带与人体组织的透明窗口光谱重叠，这些纳米粒子成为相关的亚组织光学探针。对于优化 Nd³⁺：LaF₃ 纳米粒子发光亮度的钕含量，已经证明了几毫米的亚组织穿透深度。同时，人们发现 Nd³⁺：LaF₃ 纳米粒子的红外发射带具有显著的热灵敏度，因此它们可以作为亚组织热传感的发光纳米温度计。在这项工作中已经证明了这种可能性：Nd³⁺：LaF₃ 纳米粒子已被用于在单束等离子体介导的加热实验中提供对亚组织温度的光学控制。在这个实验中，金纳米棒被用作纳米加热器，而 Nd³⁺：LaF₃ 纳米粒子则用于热读数。因此，指出了实现真正的单束控制亚组织过热过程的可能性。
