甲状腺激素在糖尿病和饥饿大鼠中生长介素-C水平降低方面的可能作用。

Possible role of thyroid hormone in decreased somatomedin-C levels in diabetic and starved rats.

作者信息

Ikeda T, Fujiyama K, Hoshino T, Takeuchi T, Mashiba H, Tominaga M

机构信息

First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.

出版信息

Ann Nutr Metab. 1990;34(1):8-12. doi: 10.1159/000177564.

DOI:10.1159/000177564

PMID:2331141

Abstract

To elucidate the possible role of thyroid hormone in somatomedin-C (SmC)/insulin-like growth factor I regulation in diabetes mellitus and starvation, plasma SmC, liver SmC, and kidney SmC concentrations were measured in streptozotocin-induced (60 mg/kg) diabetic and starved (for 72 h) rats. Triiodothyronine (T3, 5.0 micrograms/kg every 24 h) was subcutaneously injected into diabetic rats for 7 days and into starved rats at 12, 36, and 60 h after starvation. Plasma T3, plasma SmC, liver SmC, and kidney SmC concentrations were significantly decreased in diabetic and starved rats. T3 administration restored plasma T3 levels to the normal value in diabetic and starved rats. Plasma SmC and kidney SmC concentrations were significantly increased in T3-treated starved rats, while they were not increased in T3-treated diabetic rats. These results suggest that thyroid hormone may have some role in SmC regulation during starvation, but may have no role in diabetes mellitus in the rat.

摘要

为阐明甲状腺激素在糖尿病和饥饿状态下对生长调节素C（SmC）/胰岛素样生长因子I调节中的可能作用，我们测定了链脲佐菌素诱导（60mg/kg）的糖尿病大鼠和饥饿（72小时）大鼠的血浆SmC、肝脏SmC和肾脏SmC浓度。对糖尿病大鼠皮下注射三碘甲状腺原氨酸（T3，每24小时5.0微克/千克），持续7天；对饥饿大鼠在饥饿后12、36和60小时皮下注射T3。糖尿病大鼠和饥饿大鼠的血浆T3、血浆SmC、肝脏SmC和肾脏SmC浓度均显著降低。给予T3可使糖尿病大鼠和饥饿大鼠的血浆T3水平恢复至正常。T3治疗的饥饿大鼠血浆SmC和肾脏SmC浓度显著升高，而T3治疗的糖尿病大鼠则未升高。这些结果表明，甲状腺激素在饥饿期间对SmC调节可能有一定作用，但在大鼠糖尿病中可能无作用。