营养不良中 GH 抵抗的决定因素。
Determinants of GH resistance in malnutrition.
机构信息
Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 457, Boston, Massachusetts 02114, USA.
出版信息
J Endocrinol. 2014 Jan 27;220(3):R57-65. doi: 10.1530/JOE-13-0477. Print 2014 Mar.
Abstract
States of undernutrition are characterized by GH resistance. Decreased total energy intake, as well as isolated protein-calorie malnutrition and isolated nutrient deficiencies, result in elevated GH levels and low levels of IGF1. We review various states of malnutrition and a disease state characterized by chronic undernutrition - anorexia nervosa - and discuss possible mechanisms contributing to the state of GH resistance, including fibroblast growth factor 21 and Sirtuin 1. We conclude by examining the hypothesis that GH resistance is an adaptive response to states of undernutrition, in order to maintain euglycemia and preserve energy.
摘要
营养不良的状态表现为生长激素抵抗。总能量摄入减少，以及单纯的蛋白质-热量营养不良和单纯的营养缺乏，导致生长激素水平升高和 IGF1 水平降低。我们回顾了各种营养不良状态和一种以慢性营养不良为特征的疾病状态——神经性厌食症，并讨论了导致生长激素抵抗的可能机制，包括成纤维细胞生长因子 21 和 Sirtuin 1。最后，我们考察了生长激素抵抗是对营养不良状态的一种适应性反应的假说，以维持血糖正常和保存能量。
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3
The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice.
Endocrinology. 2013 Jan;154(1):263-9. doi: 10.1210/en.2012-1849. Epub 2012 Nov 13.
4
The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction.
PLoS One. 2012;7(2):e32100. doi: 10.1371/journal.pone.0032100. Epub 2012 Feb 21.
5
Effect of a high-protein diet on ghrelin, growth hormone, and insulin-like growth factor-I and binding proteins 1 and 3 in subjects with type 2 diabetes mellitus.
Metabolism. 2011 Sep;60(9):1300-11. doi: 10.1016/j.metabol.2011.01.016. Epub 2011 Mar 15.
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Sirtuin-1 regulation of mammalian metabolism.
Trends Mol Med. 2011 Jan;17(1):8-13. doi: 10.1016/j.molmed.2010.09.005.
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