Department of Medical, Surgical and Health Sciences, School of Dentistry, University of Trieste, Trieste, Italy.
Orthod Craniofac Res. 2013 Feb;16(1):1-19. doi: 10.1111/ocr.12005. Epub 2012 Sep 17.
To assess the scientific evidence for detectable volume changes of gingival crevicular fluid (GCF) incident to orthodontic tooth movement (OTM). A literature survey of longitudinal split-mouth studies was performed searching PubMed, SCOPUS and the Cochrane Library, with the last access in 15 April 2012. After selection, 13 articles qualified for the final analysis. One study was judged to be of medium/high quality, six were of medium quality and the rest of low quality. Across all studies, there was very little or no statistically significant change in GCF volume incident to OTM. The changes seen were generally ascribed to the clinical or subclinical inflammation consequent to placement of the fixed orthodontic appliance. A reappraisal of the data provided in these studies was performed by comparing the GCF volume from the test (moved) and control (non-moved) teeth, in terms of effects-size (ES) coefficients and variations, as percentages. Generally, the ES coefficients and the variations were below 1.0 and 20%, respectively. Therefore, when using current methods to collect and measure GCF volume, there was no meaningful diagnostic potential for the GCF volume as an index of tissue remodelling incident to OTM. The GCF volume is not a reliable index for tissue remodelling incident to OTM.
为了评估与正畸牙齿移动（OTM）相关的龈沟液（GCF）可检测体积变化的科学证据。通过搜索 PubMed、SCOPUS 和 Cochrane Library 进行了纵向分口研究的文献调查，最后一次访问时间为 2012 年 4 月 15 日。经过选择，有 13 篇文章符合最终分析的条件。一项研究被评为中/高质量，六项为中质量，其余为低质量。在所有研究中，与 OTM 相关的 GCF 体积几乎没有或没有统计学上的显著变化。观察到的变化通常归因于固定正畸器械放置后临床或亚临床炎症。通过比较试验（移动）和对照（未移动）牙齿的 GCF 体积，以效应大小（ES）系数和变化百分比的形式，重新评估这些研究中提供的数据。通常，ES 系数和变化分别低于 1.0 和 20%。因此，当使用当前方法收集和测量 GCF 体积时，GCF 体积作为 OTM 相关组织重塑的指标没有有意义的诊断潜力。GCF 体积不是 OTM 相关组织重塑的可靠指标。
