使用微脉冲振动装置检测龈沟液生物标志物：一项初步研究。

The gingival crevicular fluid biomarkers with micropulse vibration device: A pilot study.

作者信息

Luo Liying, Xu Chengling, Li Yao, Hao Chunbo, Zheng Jiao, Jin Xiao, Yu Jiani, Zhu Yuchang, Guan Zhiqiang, Yin Qin

机构信息

Department of Ophthalmology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Administration Department of Nosocomial Infection, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Heliyon. 2024 May 28;10(12):e31982. doi: 10.1016/j.heliyon.2024.e31982. eCollection 2024 Jun 30.

DOI:10.1016/j.heliyon.2024.e31982

PMID:38994044

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11237842/

Abstract

PURPOSE

The aim of this study is to investigate the impact of vibration stimulation on gingival crevicular fluid biomarkers and orthodontic tooth movement.

METHODS

Forty patients were randomly assigned to receive therapy with an intraoral vibration device (n = 20, AcceleDent®) or no treatment (n = 20) at a university orthodontic clinic. The quantity of fluid in the gingival sulcus, biomarkers of each fluid in the gingival sulcus, and orthodontic tooth movement were analyzed at three-time intervals (T1, T2, T3) before and after therapy (T0).

RESULTS

The results showed that vibration treatment led to higher levels of osteoclast biomarkers (RNAKL, RANKL/OPG) and inflammatory biomarkers (TNF-, IL-11, IL-18) compared to the control group. Additionally, vibration treatment at T1, T2, and T3 significantly improved tooth mobility and GCF volume. The gingival crevicular fluid biomarker levels of the T0, T1, and T2 vibration groups, as well as IL-11, IL-18, TGF-1, and TNF-α vibration groups, were significantly higher than those of the control group at different time points.

CONCLUSION

vibration therapy was found to be closely associated with bone-breaking cells and inflammatory factor levels.

摘要

目的

本研究旨在探讨振动刺激对龈沟液生物标志物和正畸牙齿移动的影响。

方法

在一所大学正畸诊所，40例患者被随机分为两组，一组使用口腔内振动装置（n = 20，AcceleDent®）进行治疗，另一组（n = 20）不接受治疗。在治疗前（T0）和治疗后的三个时间间隔（T1、T2、T3）分析龈沟液量、龈沟液中各液体的生物标志物以及正畸牙齿移动情况。

结果

结果显示，与对照组相比，振动治疗导致破骨细胞生物标志物（RNAKL、RANKL/OPG）和炎症生物标志物（TNF-、IL-11、IL-18）水平升高。此外，在T1、T2和T3进行振动治疗可显著改善牙齿松动度和龈沟液量。在不同时间点，T0、T1和T2振动组以及IL-11、IL-18、TGF-1和TNF-α振动组的龈沟液生物标志物水平显著高于对照组。