通过选择性剪接 PGC-1α 产生肌肉或线粒体。
Making muscle or mitochondria by selective splicing of PGC-1α.
机构信息
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Cell Metab. 2013 Jan 8;17(1):3-4. doi: 10.1016/j.cmet.2012.12.008.
Abstract
Endurance training induces the transcriptional coactivator PGC-1α in skeletal muscle, promoting mitochondrial biogenesis and skeletal muscle remodeling. In a recent issue of Cell, Ruas et al. (2012) show that resistance training regulates the splicing of a novel isoform of PGC-1α (PGC-1α4), which is sufficient to stimulate skeletal muscle hypertrophy.
摘要
耐力训练会在骨骼肌中诱导转录共激活因子 PGC-1α 的产生，从而促进线粒体生物发生和骨骼肌重塑。在最近一期的《细胞》杂志上，Ruas 等人（2012）表明，抗阻训练调节了一种新型 PGC-1α（PGC-1α4）异构体的剪接，这种异构体足以刺激骨骼肌肥大。
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