Robert and Arlene Kogod Center on Aging, Department of Physical Medicine and Rehabilitation, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E3-10. doi: 10.1152/ajpendo.00512.2010. Epub 2010 Nov 2.
Skeletal muscle exhibits remarkable plasticity with respect to its metabolic properties. Recent work has shown that interventions such as resistance training, genetic alterations and pharmacological strategies that increase muscle mass and glycolytic capacity, and not necessarily oxidative competence, can improve body composition and systemic metabolism. We review here recent advances in our understanding of the signaling and transcriptional regulatory pathways of this strategy and review new evidence obtained from mice and humans that supports the notion that increasing muscle mass and glycolytic capacity may effectively counter insulin resistance and type 2 diabetes mellitus.
骨骼肌在其代谢特性方面表现出显著的可塑性。最近的研究表明，增加肌肉质量和糖酵解能力的干预措施，如抗阻训练、基因改变和药物策略，而不一定是氧化能力，可以改善身体成分和全身代谢。在这里，我们回顾了对这种策略的信号转导和转录调控途径的最新理解，并回顾了从小鼠和人类获得的新证据，支持了增加肌肉质量和糖酵解能力可以有效对抗胰岛素抵抗和 2 型糖尿病的观点。
