Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-University, Munich, Germany.
Mol Immunol. 2013 Aug;55(1):70-5. doi: 10.1016/j.molimm.2012.12.008. Epub 2013 Jan 10.
Site-directed trafficking of polymorphonuclear neutrophils (PMN) to their target regions within the tissue is an important prerequisite for efficient host defense during the acute inflammatory response. This process requires intraluminal crawling of PMN on the activated endothelial cells to their extravasation sites. Upon transendothelial diapedesis, PMN migrate in the interstitial tissue to sites of inflammation. These crucial steps within the recruitment cascade are defined as intraluminal crawling and interstitial migration. In this review, we will focus on the molecular mechanisms that control and fine-tune these migratory processes and discuss the role of adhesion molecules of the β2 integrin (CD11/CD18) family for these cellular functions.
PMN 向组织内靶位的定向趋化是急性炎症反应中宿主有效防御的重要前提。此过程需要 PMN 在激活的内皮细胞上管腔爬行至其穿出部位。穿过血管内皮后，PMN 在间质组织中迁移至炎症部位。招募级联中的这些关键步骤被定义为管腔爬行和间质迁移。在本综述中，我们将重点讨论控制和微调这些迁移过程的分子机制，并讨论β2 整合素（CD11/CD18）家族的黏附分子在这些细胞功能中的作用。
