Vanderbilt Evidence-based Practice Center, Vanderbilt University, #27166-719 Thompson Lane, Nashville, TN 37204-3195, USA.
J Clin Epidemiol. 2013 Jul;66(7):719-25. doi: 10.1016/j.jclinepi.2012.03.013. Epub 2013 Jan 9.
This article describes the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to classifying the direction and strength of recommendations. The strength of a recommendation, separated into strong and weak, is defined as the extent to which one can be confident that the desirable effects of an intervention outweigh its undesirable effects. Alternative terms for a weak recommendation include conditional, discretionary, or qualified. The strength of a recommendation has specific implications for patients, the public, clinicians, and policy makers. Occasionally, guideline developers may choose to make "only-in-research" recommendations. Although panels may choose not to make recommendations, this choice leaves those looking for answers from guidelines without the guidance they are seeking. GRADE therefore encourages panels to, wherever possible, offer recommendations.
本文介绍了推荐评估、制定与评估分级（GRADE）方法，用于对推荐意见的方向和强度进行分级。推荐意见的强度分为强弱两种，其定义为人们对干预措施的有利影响超过其不利影响的把握程度。弱推荐的替代术语包括有条件的、自由决定的或有条件的。推荐意见的强度对患者、公众、临床医生和政策制定者具有特定的意义。偶尔，指南制定者可能会选择做出“仅在研究中”的推荐。尽管专家组可能选择不提出建议，但这样的选择会使那些从指南中寻求答案的人得不到他们所寻求的指导。因此，GRADE 鼓励专家组尽可能提出建议。
