Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.
J Reprod Immunol. 2013 Mar;97(1):112-9. doi: 10.1016/j.jri.2012.07.008. Epub 2013 Jan 10.
Understanding the mechanisms of term and preterm cervical remodeling is essential to prevent prematurity. Is preterm cervical remodeling caused by the same mechanisms that cause cervical remodeling at term, and are these changes accelerated in time? This question has been pondered by obstetricians seeking strategies to prevent preterm labor for many years. Mice represent an informative model of preterm birth. Thus, in this review we discuss the recent findings from mouse models that identify and characterize the initiators and cellular effectors of cervical remodeling at term and preterm labor/delivery. These studies suggest that similarities and differences exist between term and preterm cervical remodeling. Complement is an initiator or mediator in preterm labor/delivery, but is not involved in the physiological process that leads to term delivery. Therefore, complememt constitutes a specific and selective target for potentially preventing preterm delivery, thus improving neonatal health.
了解足月和早产宫颈重塑的机制对于预防早产至关重要。早产宫颈重塑是否由导致足月宫颈重塑的相同机制引起，这些变化是否随着时间的推移而加速？多年来，许多寻求预防早产策略的产科医生一直在思考这个问题。小鼠代表了一种有意义的早产模型。因此，在这篇综述中，我们讨论了最近从小鼠模型中得出的发现，这些发现确定并描述了足月和早产分娩/分娩时宫颈重塑的启动子和细胞效应子。这些研究表明，足月和早产宫颈重塑之间存在相似之处和差异。补体是早产分娩/分娩的启动子或介质，但不参与导致足月分娩的生理过程。因此，补体构成了预防早产的特定和选择性靶点，从而改善新生儿健康。
