Calvin S, Weinstein L, Witte M H, Finley P R
Department of Obstetrics, University Medical Center, Tucson, Arizona.
Am J Perinatol. 1990 Apr;7(2):125-9. doi: 10.1055/s-2007-999462.
Plasma fibronectin and prostacyclin levels have been reported to vary in preeclamptic women when compared with pregnant control women. Elevation of fibronectin and deficiency of prostacyclin have been postulated to be due to endothelial cell disruption or dysfunction. Eighteen preeclamptic women and 19 normal pregnant controls were evaluated for plasma levels of fibronectin and the prostacyclin metabolite 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha). 6-keto-PGF1 alpha and fibronectin plasma levels in patients were significantly different from control patients, with preeclamptic patients exceeding control subjects. Five patients had serial samples of 6-keto-PGF1 alpha prior to, during, and after intravenous magnesium sulfate therapy and no consistent effect was noted. No correlation existed between fibronectin and 6-keto-PGF1 alpha levels or between either compound and platelet count or liver function tests. Despite an overall elevation of fibronectin in preeclamptic patients, two patients with the hemolysis, elevated liver tests, and low platelet count syndrome showed low normal fibronectin levels coinciding with thrombocytopenia, hemolysis, and liver dysfunction. The magnitude of fibronectin elevation may therefore not predict the severity of preeclampsia. The significance of these findings is discussed.
据报道，与正常妊娠女性相比，先兆子痫女性的血浆纤连蛋白和前列环素水平存在差异。有人推测，纤连蛋白升高和前列环素缺乏是由于内皮细胞破坏或功能障碍所致。对18例先兆子痫女性和19例正常妊娠对照者的血浆纤连蛋白水平以及前列环素代谢产物6-酮-前列腺素F1α（6-keto-PGF1α）进行了评估。患者的6-keto-PGF1α和纤连蛋白血浆水平与对照患者有显著差异，先兆子痫患者高于对照受试者。5例患者在静脉注射硫酸镁治疗前、治疗期间和治疗后采集了6-keto-PGF1α的系列样本，未发现一致的效果。纤连蛋白与6-keto-PGF1α水平之间，以及这两种化合物与血小板计数或肝功能检查之间均无相关性。尽管先兆子痫患者的纤连蛋白总体升高，但两名患有溶血、肝酶升高和血小板减少综合征的患者纤连蛋白水平正常偏低，同时伴有血小板减少、溶血和肝功能障碍。因此，纤连蛋白升高的幅度可能无法预测先兆子痫的严重程度。本文讨论了这些发现的意义。
