Lutton C, Ouguerram K, Sauvage M, Magot T
Laboratoire de Physiologie de la Nutrition, URA D.0646 CNRS, Université de Paris-Sud, Orsay, France.
Reprod Nutr Dev. 1990;30(1):97-101. doi: 10.1051/rnd:19900110.
The turnover and tissular uptake of HDL (d 1.095-1.21) have been compared in normocholesterolemic or genetically hypercholesterolemic rats by a constant infusion method of [14C] sucrose labelled HDL for 8 h. The HDL clearance rate was not significantly smaller in the RICO than in the normocholesterolemic animal (320 +/- 22 microliters.h-1 versus 366 +/- 24 microliters.h-1 per 100 g of rat). It was the same case for the fractional catabolic rate, respectively equal to 7.8 and 9.4 +/- 0.6%.h-1. For both strains, liver and skeletal muscle were the main catabolic sites for HDL. The HDL uptake rates in intestine or kidney were 3-4-fold smaller than those in the liver. In the RICO rat, intestine, testis and adrenals showed a lesser HDL uptake capacity (expressed per g of organ) than the normocholesterolemic rat.
通过对[14C]蔗糖标记的高密度脂蛋白（HDL，密度1.095 - 1.21）进行8小时的持续输注法，比较了正常胆固醇血症或遗传性高胆固醇血症大鼠中HDL的周转率和组织摄取情况。RICO大鼠的HDL清除率与正常胆固醇血症动物相比并无显著降低（每100克大鼠分别为320±22微升·小时-1和366±24微升·小时-1）。分解代谢率也是如此，分别为7.8%和9.4±0.6%·小时-1。对于这两种品系，肝脏和骨骼肌是HDL的主要分解代谢部位。肠道或肾脏中HDL的摄取率比肝脏中的小3 - 4倍。在RICO大鼠中，肠道、睾丸和肾上腺的HDL摄取能力（以每克器官表示）低于正常胆固醇血症大鼠。
