Southorn Bryony, Manor Esther, Bodner Lipa, Spedding Anne V, Brennan Peter A
Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, United Kingdom.
J Oral Maxillofac Surg. 2013 Apr;71(4):805-8. doi: 10.1016/j.joms.2012.09.006. Epub 2013 Jan 11.
A 32-year-old female underwent an extracapsular dissection for a pleomorphic adenoma (PA) of the parotid gland. Six months later, she presented with an increasing lump on the upper lip that, following excision, was confirmed to be a second PA. Formalin-fixed paraffin embedded tissues were analyzed for chromosomal aberrations. Comparative genomic hybridization analysis showed multiple chromosomal aberrations in the parotid PA. In comparison, no chromosomal aberrations were found in the lip PA. To our knowledge, metachronous benign pleomorphic adenomas occurring in both a major and minor salivary gland is unreported, and furthermore, there are no comparative genomic hybridization reports of this rare occurrence. We discuss the clinicopathological implications.
一名32岁女性因腮腺多形性腺瘤（PA）接受了包膜外切除术。六个月后，她上唇出现一个不断增大的肿块，切除后经证实为第二个PA。对福尔马林固定石蜡包埋组织进行染色体畸变分析。比较基因组杂交分析显示腮腺PA存在多个染色体畸变。相比之下，唇PA未发现染色体畸变。据我们所知，主、小涎腺均发生异时性良性多形性腺瘤的情况未见报道，此外，对于这种罕见情况也没有比较基因组杂交的报告。我们讨论了其临床病理意义。
