Laboratoire de Psychologie Médicale et d'Addictologie, ULB Neuroscience Institute (UNI), Université Libre de Bruxelles (ULB), Belgium.
Neuroimage. 2013 May 1;71:92-103. doi: 10.1016/j.neuroimage.2012.12.077. Epub 2013 Jan 11.
Faces are multi-dimensional stimuli conveying parallel information about identity and emotion. Although event-related potential (ERP) studies have disclosed a P300 component in oddball responses to both deviant identity and emotional target faces, it is hypothesized that partially different neural processes should subtend emotion vs. identity within the core network of face processing. In the present study, we used simultaneous ERP-fMRI recordings and ERP-informed analysis of functional magnetic resonance imaging (fMRI) data to evidence the specific neural networks underlying P300 generation in response to different deviant emotional vs. identity faces.
18 participants were scanned during a visual oddball task in which they had to detect 3 types of deviant faces representing a change in emotion-fear or happiness-or in identity, within a series of frequent neutral ones. Amplitude and latency parameters of the P300 component, recorded for each type of deviant faces, were used to constrain fMRI analyses.
Analysis of fMRI data informed by single-trial parameters of the P300 component disclosed specific activation patterns for fearful, happy and identity deviant faces. For fearful faces, P300 amplitudes were associated with BOLD changes in the left fusiform gyrus whereas latencies were linked to left superior orbito-frontal and right fusiform activations. P300 amplitude modulations for happy deviant faces involved the left posterior cingulate gyrus and right parahippocampal regions whereas P300 latencies related to the right insula and left caudate regions. Finally, identity deviant faces were associated with widespread activities involving cortical and subcortical regions when P300 amplitudes were considered, and P300 latencies were associated with activity in right hippocampal/parahippocampal regions.
Our results suggest the existence of differential cerebral functional processes involved in the responses to deviant face stimuli, depending on the quality of the deviance (fear vs. happiness vs. identity).
面部是传递有关身份和情感的并行信息的多维刺激物。尽管事件相关电位（ERP）研究已经揭示了在对异常身份和情感目标面孔的反应中出现 P300 成分，但假设在面部处理的核心网络中，应该存在部分不同的神经过程来支撑情绪与身份。在本研究中，我们使用同时进行的 ERP-fMRI 记录和 ERP 指导的功能磁共振成像（fMRI）数据分析，以证明不同异常情绪与身份面孔反应中 P300 产生的特定神经网络。
18 名参与者在视觉Oddball 任务中接受扫描，他们必须在一系列频繁的中性面孔中检测 3 种不同类型的异常面孔，这些面孔代表情绪（恐惧或幸福）或身份的变化。记录每种异常面孔的 P300 成分的幅度和潜伏期参数，用于约束 fMRI 分析。
由 P300 成分的单试参数指导的 fMRI 数据分析揭示了恐惧、快乐和身份异常面孔的特定激活模式。对于恐惧面孔，P300 幅度与左侧梭状回的 BOLD 变化相关，而潜伏期与左侧额上回和右侧梭状回的激活相关。对于快乐异常面孔，P300 幅度调制涉及左侧后扣带回和右侧海马旁回区域，而 P300 潜伏期与右侧岛叶和左侧尾状核区域相关。最后，当考虑 P300 幅度时，身份异常面孔与涉及皮质和皮质下区域的广泛活动相关，而 P300 潜伏期与右侧海马/海马旁回区域的活动相关。
我们的结果表明，对于异常面孔刺激的反应中存在不同的大脑功能过程，具体取决于变异性的质量（恐惧与幸福与身份）。
