Hosseini S Hamed, Enferadi Milad, Sadeghi Mahdi
Department of Biomedical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Appl Radiat Isot. 2013 Mar;73:109-15. doi: 10.1016/j.apradiso.2012.12.002. Epub 2012 Dec 12.
The purpose of this study is to perform absorbed dose calculations based on Monte Carlo simulations for a novel beta emitter bioglass Ho-166 seed which is proposed for treating small hepatocellular carcinomas (HCCs). The bioactive glass seed has been developed by use of the sol-gel method. Monte Carlo simulations were carried out for the seed using the version 5 of the (MCNP) Monte Carlo radiation transport code to investigate the dosimetric parameters recommended by the AAPM Task Group 60 (TG-60). Dose distributions due to the beta and photon radiation were obtained at different radial distances surrounding the source. The dose rate in water at the reference point was calculated to be 6.71 ± 0.4 cGy h(-1) μCi(-1). The anisotropy function values ranging from 0.745 to 1.928 were obtained for radial distances of 0.3-8 mm and polar angles of 0°-90°. The (166)Ho seed source can deliver high radiation doses to the tumor, while the short range of the beta particles limits damage to the adjacent normal tissue.
本研究的目的是基于蒙特卡罗模拟，对一种新型的用于治疗小肝细胞癌（HCC）的β发射体生物玻璃Ho-166种子进行吸收剂量计算。这种生物活性玻璃种子是通过溶胶-凝胶法研制的。使用蒙特卡罗辐射传输代码（MCNP）第5版对该种子进行蒙特卡罗模拟，以研究美国医学物理师协会任务组60（TG-60）推荐的剂量学参数。在源周围不同径向距离处获得了β射线和光子辐射引起的剂量分布。参考点处水中的剂量率计算为6.71±0.4 cGy h(-1) μCi(-1)。对于0.3 - 8 mm的径向距离和0° - 90°的极角，各向异性函数值在0.745至1.928之间。(166)Ho种子源可向肿瘤提供高辐射剂量，而β粒子的短射程限制了对相邻正常组织的损伤。
