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应用蒙特卡罗代码 PENELOPE 对 192Ir 近距离放射治疗源进行剂量学特性描述。

Dosimetric characterization of an 192Ir brachytherapy source with the Monte Carlo code PENELOPE.

机构信息

Servicio de Radiofísica Hospitalaria, Hospital R.U. Carlos Haya, Av. Carlos Haya s/n, 29010 Málaga, Spain.

出版信息

Phys Med. 2010;26(3):132-9. doi: 10.1016/j.ejmp.2009.11.001. Epub 2010 Jan 14.

Abstract

Monte Carlo calculations are highly spread and settled practice to calculate brachytherapy sources dosimetric parameters. In this study, recommendations of the AAPM TG-43U1 report have been followed to characterize the Varisource VS2000 (192)Ir high dose rate source, provided by Varian Oncology Systems. In order to obtain dosimetric parameters for this source, Monte Carlo calculations with PENELOPE code have been carried out. TG-43 formalism parameters have been presented, i.e., air kerma strength, dose rate constant, radial dose function and anisotropy function. Besides, a 2D Cartesian coordinates dose rate in water table has been calculated. These quantities are compared to this source reference data, finding results in good agreement with them. The data in the present study complement published data in the next aspects: (i) TG-43U1 recommendations are followed regarding to phantom ambient conditions and to uncertainty analysis, including statistical (type A) and systematic (type B) contributions; (ii) PENELOPE code is benchmarked for this source; (iii) Monte Carlo calculation methodology differs from that usually published in the way to estimate absorbed dose, leaving out the track-length estimator; (iv) the results of the present work comply with the most recent AAPM and ESTRO physics committee recommendations about Monte Carlo techniques, in regards to dose rate uncertainty values and established differences between our results and reference data. The results stated in this paper provide a complete parameter collection, which can be used for dosimetric calculations as well as a means of comparison with other datasets from this source.

摘要

蒙特卡罗计算是一种广泛应用于计算近距离治疗源剂量学参数的方法。在本研究中,遵循了 AAPM TG-43U1 报告的建议,对瓦里安肿瘤系统提供的 Varisource VS2000(192)Ir 高剂量率源进行了特征描述。为了获得该源的剂量学参数,我们使用 PENELoPE 代码进行了蒙特卡罗计算。给出了 TG-43 形式参数,即空气比释动能强度、剂量率常数、径向剂量函数和各向异性函数。此外,还计算了水模中二维笛卡尔坐标系的剂量率。将这些量与该源的参考数据进行了比较,发现结果非常吻合。本研究的数据在以下几个方面补充了已发表的数据:(i)在体模环境条件和不确定性分析方面遵循了 TG-43U1 建议,包括统计(A 类)和系统(B 类)贡献;(ii)对该源进行了 PENELoPE 代码基准测试;(iii)蒙特卡罗计算方法与通常发表的方法不同,在估计吸收剂量时省略了轨迹长度估计器;(iv)本工作的结果符合 AAPM 和 ESTRO 物理委员会关于蒙特卡罗技术的最新建议,在剂量率不确定性值和我们的结果与参考数据之间的差异方面。本文所述的结果提供了完整的参数集,可用于剂量计算,并可与该源的其他数据集进行比较。

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