Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
J Ethnopharmacol. 2013 Mar 27;146(2):465-81. doi: 10.1016/j.jep.2012.12.051. Epub 2013 Jan 9.
Callicarpa L. (Verbenaceae) has been used for centuries in Traditional Chinese Medicine (TCM) for the prevention and treatment of a wide number of health disorders such as inflammation, rheumatism, hematuria, fracture, hematemesis, menoxenia, gastrointestinal bleeding, scrofula, etc.
To assess the scientific evidence for therapeutic Callicarpa in TCM and to identify future research needs.
The available information on the ethnopharmacological uses in Chinese medicine, phytochemistry, pharmacology and clinical practice of Callicarpa species was collected via a library and electronic search (PubMed, ScienceDirect, Google Scholar and CNKI).
A variety of ethnomedical use of Callicarpa has been recorded in many ancient Chinese books. Phytochemical investigation of this genus has resulted in identification of more than 200 chemical constituents, among which diterpenes, triterpenoids and flavonoids are the predominant groups. The isolates and crude extract have exhibited a wide spectrum of in vitro and in vivo pharmacological effects involving anti-inflammatory, hemostatic, neuroprotective, anti-amnesic, antitubercular, antioxidant, antimicrobial and analgesic activities. Preparations containing Callicarpa species exerted good efficacy on clinical applications of gynecological inflammation, internal and external hemorrhage as well as acne vulgaris and chronic pharyngitis, etc. From the toxicity perspective, only three Callicarpa species have been assessed.
Pharmacological results have validated the use of Callicarpa species in the traditional medicine. As literature demonstrated, terpenoids and flavonoids are perhaps responsible for most of the activities shown by the plants of this genus. However, the detailed active compounds and the underlying mechanisms remain a work in progress. In addition, more attention should be paid to C. nudiflora as well as the domain of rheumatism.
马鞭草科（马鞭草科）在传统中药（TCM）中已被使用了几个世纪，用于预防和治疗许多健康疾病，如炎症、风湿病、血尿、骨折、呕血、月经不调、胃肠道出血、瘰疬等。
评估 TCM 中治疗性假马齿苋的科学证据，并确定未来的研究需求。
通过图书馆和电子搜索（PubMed、ScienceDirect、Google Scholar 和 CNKI）收集有关马鞭草科植物在中药中的民族药理学用途、植物化学、药理学和临床实践的可用信息。
许多中国古代书籍都记录了马鞭草的各种民族医学用途。对该属植物的化学研究已鉴定出 200 多种化学成分，其中二萜、三萜和类黄酮是主要的化合物。分离物和粗提取物表现出广泛的体外和体内药理作用，涉及抗炎、止血、神经保护、抗健忘、抗结核、抗氧化、抗菌和镇痛活性。含有马鞭草科植物的制剂在妇科炎症、内外出血以及痤疮和慢性咽炎等临床应用中表现出良好的疗效。从毒性角度来看，只有三种马鞭草科植物进行了评估。
药理结果验证了马鞭草科植物在传统医学中的应用。正如文献所示，萜类化合物和类黄酮可能是该属植物表现出大多数活性的原因。然而，详细的活性化合物和潜在机制仍在进行中。此外，应该更加关注无毛假马齿苋以及风湿病领域。
