Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, USA.
Ophthalmic Plast Reconstr Surg. 2013 May-Jun;29(3):e73-5. doi: 10.1097/IOP.0b013e318272d497.
A 49-year-old woman with acute myeloid leukemia, FAB M1 subtype, and 12p deletion, presented with progressive right proptosis and diplopia for 1 week. Orbital CT revealed a homogenously enhancing, orbital mass engulfing the inferior rectus muscle. Histopathology revealed myeloid sarcoma for which she underwent external beam radiotherapy. Subsequently, there was no sign of local recurrence, but she succumbed to leukemia involving the central nervous system. This is the first case, to the authors' knowledge, of an orbital sarcoma of FAB M1 myeloblasts bearing a 12p deletion.
一位 49 岁女性，患有 FAB M1 亚型急性髓系白血病和 12p 缺失，出现进行性右眼突出和复视 1 周。眼眶 CT 显示均匀强化的眼眶肿块包绕下直肌。组织病理学显示髓性肉瘤，为此她接受了外照射放疗。随后，未见局部复发迹象，但她因累及中枢神经系统的白血病而死亡。据作者所知，这是首例携带 12p 缺失的 FAB M1 髓母细胞性眼眶肉瘤病例。
