Glutamate, a metabolic biomarker of aggressiveness and a potential therapeutic target for prostate cancer.
作者信息
Koochekpour Shahriar
机构信息
Department of Cancer Genetics and Urology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
出版信息
Asian J Androl. 2013 Mar;15(2):212-3. doi: 10.1038/aja.2012.145. Epub 2013 Jan 14.
Abstract
摘要
相似文献
1
Glutamate, a metabolic biomarker of aggressiveness and a potential therapeutic target for prostate cancer.谷氨酸，一种攻击行为的代谢生物标志物以及前列腺癌的潜在治疗靶点。
Asian J Androl. 2013 Mar;15(2):212-3. doi: 10.1038/aja.2012.145. Epub 2013 Jan 14.
2
Ghrelin O-acyltransferase (GOAT) enzyme is overexpressed in prostate cancer, and its levels are associated with patient's metabolic status: Potential value as a non-invasive biomarker.胃饥饿素O-酰基转移酶（GOAT）在前列腺癌中过表达，其水平与患者的代谢状态相关：作为非侵入性生物标志物的潜在价值。
Cancer Lett. 2016 Dec 1;383(1):125-134. doi: 10.1016/j.canlet.2016.09.022. Epub 2016 Sep 28.
3
Sirtuin 7: a new marker of aggressiveness in prostate cancer.沉默调节蛋白7：前列腺癌侵袭性的新标志物。
Oncotarget. 2017 Aug 24;8(44):77309-77316. doi: 10.18632/oncotarget.20468. eCollection 2017 Sep 29.
4
Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness.生物流体中 TWEAK/Fn14 轴与选定生物标志物联合检测可改善前列腺癌侵袭性评估。
J Transl Med. 2019 Sep 9;17(1):307. doi: 10.1186/s12967-019-2053-6.
5
The impact of common genetic variations in genes of the sex hormone metabolic pathways on steroid hormone levels and prostate cancer aggressiveness.常见的性激素代谢途径基因中的遗传变异对甾体激素水平和前列腺癌侵袭性的影响。
Cancer Prev Res (Phila). 2011 Dec;4(12):2044-50. doi: 10.1158/1940-6207.CAPR-11-0283. Epub 2011 Sep 7.
6
Expression screening of cancer/testis genes in prostate cancer identifies NR6A1 as a novel marker of disease progression and aggressiveness.在前列腺癌中进行癌症/睾丸基因的表达筛选，鉴定 NR6A1 为疾病进展和侵袭性的新型标志物。
Prostate. 2013 Jul;73(10):1103-14. doi: 10.1002/pros.22659. Epub 2013 Mar 26.
7
A novel approach for assessment of prostate cancer aggressiveness using survivin-driven tumour-activatable minicircles.利用生存素驱动的肿瘤激活性微小环评估前列腺癌侵袭性的新方法。
Gene Ther. 2019 May;26(5):177-186. doi: 10.1038/s41434-019-0067-6. Epub 2019 Mar 13.
8
The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness.In1-ghrelin 剪接变异体在前列腺癌侵袭性中的致癌作用。
Mol Cancer. 2017 Aug 29;16(1):146. doi: 10.1186/s12943-017-0713-9.
9
Prostate cancer aggressiveness: in vivo assessment of MR spectroscopy and diffusion-weighted imaging at 3 T.前列腺癌侵袭性：3T 时磁共振波谱和弥散加权成像的体内评估。
Radiology. 2012 Nov;265(2):457-67. doi: 10.1148/radiol.12111744. Epub 2012 Jul 27.
10
Is there a correlation between the aggressiveness of chronic asymptomatic prostatitis National Institutes of Health category IV and the Gleason score in patients with prostate cancer?前列腺癌患者中，慢性无症状性前列腺炎美国国立卫生研究院IV型的侵袭性与Gleason评分之间是否存在相关性？
Can Urol Assoc J. 2020 Nov;14(11):E568-E573. doi: 10.5489/cuaj.6284.
引用本文的文献
1
Circulating levels of glutamate predict brain disease in patients with advanced lung and breast cancer: a prospective study.晚期肺癌和乳腺癌患者循环中谷氨酸水平可预测脑部疾病：一项前瞻性研究。
J Neurooncol. 2025 Nov;175(2):825-836. doi: 10.1007/s11060-025-05182-y. Epub 2025 Jul 28.
2
Ruminococcus and prostate cancer: new treatment opportunities on the gut-prostate axis.瘤胃球菌与前列腺癌：肠道-前列腺轴上的新治疗机遇
Med Oncol. 2025 Jul 28;42(9):387. doi: 10.1007/s12032-025-02951-7.
3
Abnormal changes in metabolites caused by mA methylation modification: The leading factors that induce the formation of immunosuppressive tumor microenvironment and their promising potential for clinical application.由mA甲基化修饰引起的代谢物异常变化：诱导免疫抑制肿瘤微环境形成的主要因素及其临床应用的潜在前景。
J Adv Res. 2025 Apr;70:159-186. doi: 10.1016/j.jare.2024.04.016. Epub 2024 Apr 25.
4
Activation of ERβ hijacks the splicing machinery to trigger R-loop formation in triple-negative breast cancer.雌激素受体β（ERβ）的激活劫持剪接机制，在三阴性乳腺癌中引发 R 环形成。
Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2306814121. doi: 10.1073/pnas.2306814121. Epub 2024 Mar 21.
5
Implications of a Neuronal Receptor Family, Metabotropic Glutamate Receptors, in Cancer Development and Progression.代谢型谷氨酸受体家族在癌症发生发展中的意义。
Cells. 2022 Sep 13;11(18):2857. doi: 10.3390/cells11182857.
6
Advances in understanding cancer-associated neurogenesis and its implications on the neuroimmune axis in cancer.对癌症相关神经发生及其对癌症神经免疫轴影响的认识进展。
Pharmacol Ther. 2022 Nov;239:108199. doi: 10.1016/j.pharmthera.2022.108199. Epub 2022 Apr 29.
7
Blood glutamate scavengers increase pro-apoptotic signaling and reduce metastatic melanoma growth in-vivo.血液谷氨酸清除剂可增加促凋亡信号，减少体内转移性黑色素瘤的生长。
Sci Rep. 2021 Jul 19;11(1):14644. doi: 10.1038/s41598-021-94183-8.
8
Compositional differences of gut microbiome in matched hormone-sensitive and castration-resistant prostate cancer.配对的激素敏感性和去势抵抗性前列腺癌中肠道微生物群的组成差异
Transl Androl Urol. 2020 Oct;9(5):1937-1944. doi: 10.21037/tau-20-566.
9
Transient coating of γ-FeO nanoparticles with glutamate for its delivery to and removal from brain nerve terminals.用谷氨酸对γ-FeO纳米颗粒进行短暂包被，以便将其递送至脑神经末梢并从其中移除。
Beilstein J Nanotechnol. 2020 Sep 10;11:1381-1393. doi: 10.3762/bjnano.11.122. eCollection 2020.
10
Osteosarcoma growth suppression by riluzole delivery via iron oxide nanocage in nude mice.氧化铁纳米笼递药瑞乐替尼抑制裸鼠骨肉瘤生长
Oncol Rep. 2020 Jan;43(1):169-176. doi: 10.3892/or.2019.7420. Epub 2019 Nov 28.
本文引用的文献
1
Serum glutamate levels correlate with Gleason score and glutamate blockade decreases proliferation, migration, and invasion and induces apoptosis in prostate cancer cells.血清谷氨酸水平与 Gleason 评分相关，谷氨酸阻断可降低前列腺癌细胞的增殖、迁移和侵袭，并诱导其凋亡。
Clin Cancer Res. 2012 Nov 1;18(21):5888-901. doi: 10.1158/1078-0432.CCR-12-1308. Epub 2012 Oct 16.
2
Application of metabolomics to prostate cancer.代谢组学在前列腺癌中的应用。
Urol Oncol. 2011 Sep-Oct;29(5):572-81. doi: 10.1016/j.urolonc.2011.08.002.
3
Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer.代谢型谷氨酸受体 1：治疗乳腺癌的潜在治疗靶点。
Breast Cancer Res Treat. 2012 Apr;132(2):565-73. doi: 10.1007/s10549-011-1624-x. Epub 2011 Jun 17.
4
Otto Warburg's contributions to current concepts of cancer metabolism.奥托·瓦尔堡对当前癌症代谢概念的贡献。
Nat Rev Cancer. 2011 May;11(5):325-37. doi: 10.1038/nrc3038. Epub 2011 Apr 14.
5
Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma.代谢型谷氨酸受体1与人类黑色素瘤中的谷氨酸信号传导
Cancer Res. 2007 Mar 1;67(5):2298-305. doi: 10.1158/0008-5472.CAN-06-3665.
6
Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia.黑色素瘤小鼠模型表明代谢型谷氨酸信号传导与黑素细胞肿瘤形成有关。
Nat Genet. 2003 May;34(1):108-12. doi: 10.1038/ng1148.
7
Plasma and erythrocyte amino acid levels in normal adult subjects fed a high protein meal with and without added monosodium glutamate.
J Nutr. 1982 Oct;112(10):1953-60. doi: 10.1093/jn/112.10.1953.
8
Plasma amino acid concentrations in normal adults fed meals with added monosodium L-glutamate and aspartame.给正常成年人喂食添加了L-谷氨酸钠和阿斯巴甜的餐食后的血浆氨基酸浓度。
J Nutr. 1983 Sep;113(9):1851-60. doi: 10.1093/jn/113.9.1851.
Zotero 插件