Department of Gastrointestinal Surgery, State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.
Dig Dis Sci. 2013 May;58(5):1264-70. doi: 10.1007/s10620-012-2513-9. Epub 2013 Jan 13.
Matrix metalloproteinase-14 (MMP-14) has been considered to play an important role in invasion and metastasis of human solid tumor.
The present study aimed to investigate the association of MMP-14 with overall survival in human gastric cancer.
Gastric cancer and adjacent normal specimens were collected from 205 patients who had not received neoadjuvant chemotherapy. MMP-14 expression was investigated by immunohistochemistry assay and staining evaluation results were analyzed statistically in relation to overall survival of patients.
MMP-14 expression proved to be increased in gastric cancer compared with that in normal tissues. It was also proved that MMP-14 expression was associated with tumor invasion, metastasis, and TNM stage while no correlations were detected between MMP-14 expression and age, sex, differentiation status, or Lauren's classification. Moreover, patients with gastric cancer of MMP-14-positive expression tend to have worse overall survival compared with those with MMP-14 negative expression.
The present study confirmed the over-expression of MMP-14 in human gastric cancer and its association with tumor progression. It also provided the first evidence that MMP-14 expression in gastric cancer was an independent negative prognostic factor of patients.
基质金属蛋白酶-14（MMP-14）被认为在人类实体瘤的侵袭和转移中发挥重要作用。
本研究旨在探讨 MMP-14 与人类胃癌总体生存率的关系。
收集了 205 例未经新辅助化疗的患者的胃癌和相邻正常标本。通过免疫组织化学检测 MMP-14 的表达，并对染色评估结果进行统计学分析，以评估其与患者总体生存率的关系。
与正常组织相比，MMP-14 在胃癌组织中表达增加。此外，MMP-14 表达与肿瘤侵袭、转移和 TNM 分期有关，而与年龄、性别、分化状态或 Lauren 分类无关。而且，MMP-14 阳性表达的胃癌患者总体生存率较 MMP-14 阴性表达的患者差。
本研究证实了 MMP-14 在人类胃癌中的过度表达及其与肿瘤进展的关系。此外，本研究首次提供了证据表明，胃癌中 MMP-14 的表达是患者独立的预后不良因素。
