Handajani Yvonne S, Djoerban Zubairi, Irawan Hendry
Department of Public Health, Faculty of Medicine, Atma Jaya Catholic University. Jl. Pluit Raya 2, Jakarta, Indonesia.
Acta Med Indones. 2012 Oct;44(4):310-6.
to provide an overview of the quality of life (OQL) for people living with HIV/AIDS (PLWHA) in Jakarta, particularly in the Kramat 128 Hospital, based on CD4 and viral load (VL) levels and the length of antiretroviral (ARV) treatment.
a cross-sectional study performed at Kramat 128 Hospital Jakarta Outpatient Clinic from November 2010 to January 2011. Quality of life was assessed with the WHOQOL-BREF instrument. The data were analyzed using Chi-Square test, independent T-test, and One-Way Analysis of Variance (ANOVA) test.
the mean score in four domains of QOL in descending order were psychological (72.27), physical health (70.10), environment (65.59), and social relationships (64.44). There were a significant differences in overall QOL (p=0.000) and general health (p=0.001) between lower and higher CD4 levels. Patients who were interviewed look healthy physically and psychologically, have a good QOL based on statistical analysis. Patients with undetectable VL levels had better in general health (p=0.012), and those with longer ARV therapy (>1 year) had better overall QOL (p=0.024) and general health (p=0.003). Analysis with four domains of QOL showed a significant relationship of CD4 levels with the physical health (p=0.001) and psychological domain (p=0.043). VL levels showed significant relationships with the four domains of QOL (p<0.05). Duration of ARV therapy showed a significant association only with physical health domain (p=0.015).
higher CD4 levels, undetectable VL, and longer ARV therapy will increase patient's QOL. Higher QOL will make the patient have ability to cope with illness. So, a better QOL can be taken as indicator of successful ARV treatment.
基于CD4和病毒载量（VL）水平以及抗逆转录病毒（ARV）治疗时长，概述雅加达，特别是克拉马特128医院中感染艾滋病毒/艾滋病（HIV/AIDS）的患者的生活质量（QOL）。
2010年11月至2011年1月在雅加达克拉马特128医院门诊进行的一项横断面研究。使用世界卫生组织生活质量简表（WHOQOL-BREF）工具评估生活质量。数据采用卡方检验、独立样本t检验和单因素方差分析（ANOVA）进行分析。
生活质量四个领域的平均得分从高到低依次为心理（72.27）、身体健康（70.10）、环境（65.59）和社会关系（64.44）。CD4水平较低和较高的患者在总体生活质量（p = 0.000）和总体健康状况（p = 0.001）方面存在显著差异。接受访谈的患者在身体和心理上看起来健康，基于统计分析，其生活质量良好。病毒载量水平不可检测的患者总体健康状况更好（p = 0.012），接受抗逆转录病毒治疗时间较长（>1年）的患者总体生活质量更好（p = 0.024），总体健康状况更好（p = 0.003）。对生活质量四个领域的分析表明，CD4水平与身体健康领域（p = 0.001）和心理领域（p = 0.043）存在显著关系。病毒载量水平与生活质量的四个领域均存在显著关系（p<0.05）。抗逆转录病毒治疗时长仅与身体健康领域存在显著关联（p = 0.015）。
较高的CD4水平、不可检测的病毒载量以及较长时间的抗逆转录病毒治疗将提高患者的生活质量。较高的生活质量将使患者有能力应对疾病。因此，较好的生活质量可作为抗逆转录病毒治疗成功的指标。
