Harangi Mariann, Zsíros Noémi, Juhász Lilla, Paragh György
Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Belgyógyászati Intézet, Anyagcsere Betegségek Tanszék Debrecen Nagyerdei krt. 98. 4032.
Orv Hetil. 2013 Jan 20;154(3):83-92. doi: 10.1556/OH.2013.29530.
Statin therapy is considered to be safe and rarely associated with serious adverse events. However, a significant proportion of patients on statin therapy show some degree of intolerance which can lead to decreased adherence to statin therapy. The authors summarize the symptoms, signs and frequencies of the most common statin-induced adverse effects and their most important risk factors including some single nucleotide polymorphisms and gene mutations. Also, they review the available approaches to detect and manage the statin-intolerant patients.
