Li S G, Li W Q, Wang J K, Zhang H Y, Li W, Zhang P, Wang X H, Zhang H X, Gu J P, Gu R J
Department of Neurology, Second Affiliated Hospital, Xinxiang Medical University, Xinxiang, China.
Genet Mol Res. 2012 Dec 19;11(4):4479-86. doi: 10.4238/2012.December.19.1.
There is structural damage to myelin and secondary immune injury in the development of delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP). In order to assess the role of genetic factors in this mechanism, we studied the association between tumor necrosis factor-α308 (TNF-α308) and myelin basic protein (MBP) 5'-side tetranucleotide repetitive sequence (TGGA) n gene polymorphism and DEACMP. We selected 109 DEACMP patients from the Han population in the Northern Henan Province as the case group, and 115 patients without delayed encephalopathy (called the acute CO poisoning group or the control group). There were no significant differences in TNF-α308 and MBP 5'-side TGGA n genotype distribution and allele frequency between the DEACMP group and the acute CO poisoning group (all P > 0.05). When the population was stratified by gender, only the MBP 5'-side TGGA n allele frequency was significantly different, and the frequency of allele L in the DEACMP group was significantly higher than that of the acute CO poisoning group in males (χ(2) = 4.089, P = 0.043, odds ratio = 2.103, 95% confidence interval = 1.014-4.363). The results showed that there was association between MBP 5'-side TGGA n gene polymorphism and DEACMP, and that allele L could increase the risk of occurrence in male patients with DEACMP. DEACMP may be the result of interaction of environmental and genetic factors.
急性一氧化碳（CO）中毒后迟发性脑病（DEACMP）的发病过程中存在髓鞘结构损伤和继发性免疫损伤。为评估遗传因素在此机制中的作用，我们研究了肿瘤坏死因子-α308（TNF-α308）和髓鞘碱性蛋白（MBP）5'-侧翼四核苷酸重复序列（TGGA）n基因多态性与DEACMP之间的关联。我们选取了豫北地区汉族人群中的109例DEACMP患者作为病例组，以及115例无迟发性脑病的患者（称为急性CO中毒组或对照组）。DEACMP组与急性CO中毒组之间TNF-α308和MBP 5'-侧翼TGGA n基因型分布及等位基因频率无显著差异（均P>0.05）。当按性别对人群进行分层时，仅MBP 5'-侧翼TGGA n等位基因频率存在显著差异，男性DEACMP组中等位基因L的频率显著高于急性CO中毒组（χ(2)=4.089，P=0.043，优势比=2.103，95%置信区间=1.014 - 4.363）。结果表明，MBP 5'-侧翼TGGA n基因多态性与DEACMP存在关联，且等位基因L可增加男性DEACMP患者的发病风险。DEACMP可能是环境因素与遗传因素相互作用的结果。
