Hara H, Kato H, Kogure K
Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, Japan.
Brain Res. 1990 Mar 5;510(2):335-8. doi: 10.1016/0006-8993(90)91386-u.
The effect of alpha-tocopherol (vitamin E) on ischemic neuronal damage was studied in the gerbil. The animals were subjected to 5 min of cerebral ischemia by bilateral common carotid artery occlusion. Immediately after ischemia, alpha-tocopherol at a dose of 50 or 100 mg/kg was administered intravenously. Morphological changes in the CA1 sector of the hippocampus were evaluated after 7 days of survival. alpha-Tocopherol prevented ischemia-induced neuronal death. The average density of CA1 pyramidal neurons (cells/mm, mean +/- S.E.M.) was 252 +/- 8 (n = 8) in the sham-operated group, 50 +/- 20 (n = 8) in the ischemia group, and 140 +/- 35 (n = 8) and 182 +/- 36 (n = 8) in the groups treated with alpha-tocopherol at the doses of 50 and 100 mg/kg, respectively. The results suggest that free radical scavenging action of alpha-tocopherol played an important role in preventing the neuronal death.
在沙鼠身上研究了α-生育酚（维生素E）对缺血性神经元损伤的影响。通过双侧颈总动脉闭塞使动物遭受5分钟的脑缺血。缺血后立即静脉注射剂量为50或100mg/kg的α-生育酚。存活7天后评估海马CA1区的形态学变化。α-生育酚可预防缺血诱导的神经元死亡。假手术组CA1锥体神经元的平均密度（细胞/mm，平均值±标准误）为252±8（n = 8），缺血组为50±20（n = 8），在分别用50和100mg/kg剂量的α-生育酚治疗的组中分别为140±35（n = 8）和182±36（n = 8）。结果表明，α-生育酚的自由基清除作用在预防神经元死亡中起重要作用。
