Araki T, Kogure K, Izumiyama K
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Acta Neurol Scand. 1989 Nov;80(5):451-4. doi: 10.1111/j.1600-0404.1989.tb03908.x.
The effect of methoxamine, an alpha 1-adrenoceptor agonist, on ischemic neuronal damage was studied in the gerbil. The animals were subjected to 5 min of ischemia by bilateral common carotid arteries occlusion. Morphological changes and calcium accumulation were evaluated in the CA1 sector of the hippocampus after 7 days of survival. The degree of ischemic neuronal damage and calcium accumulation in the methoxamine-treated groups were significantly attenuated compared with the saline-treated ischemic group. The results suggest that alpha 1-adrenoceptor stimulation prevents ischemic neuronal damage.
研究了α1 -肾上腺素能受体激动剂甲氧明对沙鼠缺血性神经元损伤的影响。通过双侧颈总动脉闭塞使动物缺血5分钟。在存活7天后，评估海马CA1区的形态学变化和钙积累情况。与生理盐水处理的缺血组相比，甲氧明处理组的缺血性神经元损伤程度和钙积累明显减轻。结果表明，刺激α1 -肾上腺素能受体可预防缺血性神经元损伤。
