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Emerging Tim-3 functions in antimicrobial and tumor immunity.Tim-3 在抗菌和肿瘤免疫中的新兴功能。
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Galectin-9 inhibits cell proliferation and induces apoptosis in Jurkat and KE-37 acute lymphoblastic leukemia cell lines caspase-3 activation.半乳糖凝集素-9抑制Jurkat和KE-37急性淋巴细胞白血病细胞系中的细胞增殖并诱导凋亡，激活半胱天冬酶-3。
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Association between polymorphisms in the promoter region of T cell immunoglobulin and mucin domain-3 and myasthenia gravis-associated thymoma.T细胞免疫球蛋白和粘蛋白结构域3启动子区域多态性与重症肌无力相关胸腺瘤的关联
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The impact of the TIM gene family on tumor immunity and immunosuppression.TIM 基因家族对肿瘤免疫和免疫抑制的影响。
Cell Mol Immunol. 2014 Jan;11(1):41-8. doi: 10.1038/cmi.2013.57. Epub 2013 Dec 16.
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The tumor microenvironment: a pitch for multiple players.肿瘤微环境：多方参与的舞台。
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本文引用的文献

1
IRF-8 controls melanoma progression by regulating the cross talk between cancer and immune cells within the tumor microenvironment.IRF-8 通过调控肿瘤微环境中肿瘤细胞与免疫细胞之间的串扰来控制黑色素瘤的进展。
Neoplasia. 2012 Dec;14(12):1223-35. doi: 10.1593/neo.121444.
2
Plasmacytoid dendritic cells and their therapeutic activity in cancer.浆细胞样树突状细胞及其在癌症中的治疗活性。
Oncoimmunology. 2012 Aug 1;1(5):726-734. doi: 10.4161/onci.20171.
3
HMGB1, TLR and RAGE: a functional tripod that leads to diabetic inflammation.HMGB1、TLR 和 RAGE：导致糖尿病炎症的功能三脚架。
Expert Opin Ther Targets. 2011 Aug;15(8):1023-35. doi: 10.1517/14728222.2011.575360. Epub 2011 May 17.
4
Regulation of immune cell homeostasis by type I interferons.I 型干扰素对免疫细胞稳态的调节。
Cytokine Growth Factor Rev. 2010 Aug;21(4):227-36. doi: 10.1016/j.cytogfr.2010.05.002. Epub 2010 Jun 2.
5
Participation of Omi Htra2 serine-protease activity in the apoptosis induced by cisplatin on SW480 colon cancer cells.Omi/HtrA2丝氨酸蛋白酶活性参与顺铂诱导SW480结肠癌细胞凋亡的过程。
J Chemother. 2008 Jun;20(3):348-54. doi: 10.1179/joc.2008.20.3.348.
6
TIM-3 in autoimmunity.自身免疫中的T细胞免疫球蛋白黏蛋白分子3（TIM-3）
Curr Opin Immunol. 2006 Dec;18(6):665-9. doi: 10.1016/j.coi.2006.09.009. Epub 2006 Oct 2.
7
RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages.RAGE是HMGB1在啮齿动物巨噬细胞中促炎活性的主要受体。
Scand J Immunol. 2005 Jan;61(1):1-9. doi: 10.1111/j.0300-9475.2005.01534.x.
8
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.Th1特异性细胞表面蛋白Tim-3调节巨噬细胞活化及自身免疫性疾病的严重程度。
Nature. 2002 Jan 31;415(6871):536-41. doi: 10.1038/415536a.

TIM-3 as a molecular switch for tumor escape from innate immunity.

作者信息

Mattei Fabrizio, Schiavoni Giovanna

机构信息

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità Rome, Italy.

出版信息

Front Immunol. 2013 Jan 9;3:418. doi: 10.3389/fimmu.2012.00418. eCollection 2012.

DOI:10.3389/fimmu.2012.00418
PMID:23316202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3540392/
Abstract
摘要