Hokkaido University, Hokkaido, Japan.
Research Center for Infection-Associated Cancer, Institute for Genetic Medicine, Hokkaido University, Hokkaido, Japan.
Cell Mol Immunol. 2014 Jan;11(1):41-8. doi: 10.1038/cmi.2013.57. Epub 2013 Dec 16.
Tumor immunoevasion is an advanced phase of cancer immunosurveillance in which tumor cells acquire the ability to circumvent host immune systems and exploit protumorigenic inflammation. T-cell immunoglobulin mucin (TIM) gene family members have emerged as critical checkpoint proteins that regulate multiple immune response phases and maintain immune homeostasis. Accumulating evidence demonstrates that tumor cells exploit TIM gene family members to evade immunosurveillance, whereas TIM gene family members facilitate the prevention of inflammation-related tumor progression. Thus, a comprehensive analysis to clarify the relative contributions of TIM gene family members in tumor progression may elucidate immunosurveillance systems in cancer patients.
肿瘤免疫逃逸是癌症免疫监视的一个高级阶段，在此阶段，肿瘤细胞获得了逃避宿主免疫系统和利用促肿瘤炎症的能力。T 细胞免疫球蛋白黏蛋白 (TIM) 基因家族成员已成为关键的检查点蛋白，可调节多种免疫反应阶段并维持免疫稳态。越来越多的证据表明，肿瘤细胞利用 TIM 基因家族成员来逃避免疫监视，而 TIM 基因家族成员则有助于防止与炎症相关的肿瘤进展。因此，全面分析以阐明 TIM 基因家族成员在肿瘤进展中的相对贡献，可能阐明癌症患者的免疫监视系统。
