Endocrine Key Laboratory of Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wangfujing, Beijing 100730, China.
Int J Endocrinol. 2012;2012:389108. doi: 10.1155/2012/389108. Epub 2012 Dec 11.
A transient increase in insulin resistance (IR) is a component of puberty. We investigated the impact of body composition and adipokines on IR during puberty in Chinese children. This study included 3223 schoolchildren aged 6-18 years. IR was calculated using homeostasis model assessment (HOMA-IR). We revealed that body mass index (BMI) and waist circumference increased gradually during puberty in both genders, while fat-mass percentage (FAT%) increased steadily only in girls. Change of leptin showed striking sexual dimorphisms: in girls leptin increased steadily during puberty, whereas in boys, after a transient rise at the beginning of puberty, leptin declined by Tanner staging even in those overweight or obese. Inversely, adiponectin level decreased significantly during puberty. In both genders, HOMA-IR started to increase at the beginning of puberty, peaked in the middle, and revised at late puberty in overweight/obesity boys while it stayed high till the end of puberty in girls and normal weight boys. Multivariate regression analysis revealed that leptin presented a stronger indicator of HOMA-IR than anthropometric measures during puberty. Our results demonstrated that gender-specific FAT% and leptin changed with pubertal development. Leptin emerged as a stronger predictor of IR than traditional anthropometric indices, suggesting a prominent role in the development of pubertal IR.
胰岛素抵抗（IR）在青春期会短暂增加。我们研究了中国儿童在青春期期间身体成分和脂肪因子对 IR 的影响。这项研究包括 3223 名 6-18 岁的在校学生。使用稳态模型评估（HOMA-IR）计算 IR。结果显示，在青春期男女的体重指数（BMI）和腰围逐渐增加，而只有女孩的脂肪量百分比（FAT%）持续稳定增加。瘦素的变化表现出明显的性别二态性：在女孩中，瘦素在青春期持续增加，而在男孩中，青春期开始时短暂上升后，瘦素在即使超重或肥胖的男孩中也会随着发育阶段下降。相反，脂联素水平在青春期显著下降。在两性中，HOMA-IR 在青春期开始时开始增加，在中期达到峰值，在超重/肥胖男孩中在后期青春期修正，而在女孩和正常体重男孩中则一直保持较高水平直至青春期结束。多元回归分析显示，在青春期，瘦素比人体测量指标更能指示 HOMA-IR。我们的结果表明，FAT%和瘦素在青春期具有性别特异性变化。瘦素作为 IR 的预测因子比传统的人体测量指标更具优势，表明其在青春期 IR 发展中具有重要作用。
