Pires Liliane Viana, González-Gil Esther M, Anguita-Ruiz Augusto, Bueno Gloria, Gil-Campos Mercedes, Vázquez-Cobela Rocío, Pérez-Ferreirós Alexandra, Moreno Luis A, Gil Ángel, Leis Rosaura, Aguilera Concepción M
Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain.
Center of Biomedical Research, Institute of Nutrition and Food Technology "José Mataix", University of Granada, Avda. del Conocimiento s/n, 18016 Armilla, Spain.
Nutrients. 2021 Dec 15;13(12):4488. doi: 10.3390/nu13124488.
Obesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76 children from the PUBMEP study, aged 4-12 years at baseline, were included. Children were evaluated in prepubertal and pubertal stages. Anthropometric measurements and selected cardiometabolic risk biomarkers, such as plasma glucose, blood lipids, insulin, adiponectin, leptin, and blood pressure, and serum 25-hydroxyvitamin D (25(OH)D) were determined. Children were categorized by obesity degree and IR status combined before and after puberty. Paired -test and multivariate linear regression analyses were conducted. During puberty, the increase in triacylglycerols, insulin, and HOMA-IR and the decrease in QUICKI were significantly associated with the reduction in 25(OH)D (B = -0.274, = 0.032; B = -0.219, = 0.019; B = -0.250, = 0.013; B = 1.574, = 0.013, respectively) after adjustment by BMI-z, sex, and pubertal stage. Otherwise, prepubertal non-IR children with overweight/obesity that became IR during puberty showed a significant decrease in 25(OH)D and HDL-c, and an increase in waist circumference and triacylglycerol concentrations ( < 0.05 for all) over time. These results suggest that changes in IR seem to be associated with an effect on 25(OH)D levels during puberty, especially in children with overweight.
即使在儿童中，肥胖和心血管代谢风险也与维生素D水平有关。本研究的目的是评估青春期前至青春期儿童的胰岛素抵抗（IR）、心血管代谢风险因素与维生素D之间的关联。共有76名来自PUBMEP研究的儿童被纳入，基线年龄为4至12岁。对儿童在青春期前和青春期进行评估。测定人体测量指标以及选定的心血管代谢风险生物标志物，如血浆葡萄糖、血脂、胰岛素、脂联素、瘦素和血压，以及血清25-羟基维生素D（25(OH)D）。根据青春期前后的肥胖程度和IR状态对儿童进行分类。进行配对检验和多元线性回归分析。在青春期，经BMI-z、性别和青春期阶段调整后，甘油三酯、胰岛素和HOMA-IR的增加以及QUICKI的降低与25(OH)D的降低显著相关（分别为B = -0.274，P = 0.032；B = -0.219，P = 0.019；B = -0.250，P = 0.013；B = 1.574，P = 0.013）。此外，青春期前超重/肥胖的非IR儿童在青春期变为IR后，25(OH)D和HDL-c显著降低，腰围和甘油三酯浓度增加（所有P均<0.05）。这些结果表明，IR的变化似乎与青春期对25(OH)D水平的影响有关，尤其是在超重儿童中。
