5号染色体缺失。膀胱癌中唯一的染色体改变。
5q deletion. The sole chromosome change in a carcinoma of the bladder.
作者信息
Atkin N B, Fox M F
机构信息
Department of Cancer Research, Mount Vernon Hospital, Northwood, Middlesex, England.
出版信息
Cancer Genet Cytogenet. 1990 May;46(1):129-31. doi: 10.1016/0165-4608(90)90019-7.
PMID:2331676
Abstract
Direct chromosome preparations of a transitional cell carcinoma of the bladder that had invaded the mucosa but not more deeply showed a 46,XY,5q- karyotype in nearly all metaphases. This is the first description of a 5q deletion, which may have been interstitial, del(5)(q13q22), as the only change in a bladder carcinoma.
摘要
对一例侵犯黏膜但未侵犯更深层的膀胱移行细胞癌进行直接染色体制备，结果显示几乎所有中期细胞的核型为46,XY,5q-。这是对5q缺失的首次描述，该缺失可能是间质性的，即del(5)(q13q22)，是膀胱癌中唯一的改变。
Zotero 插件