Section of Psychiatry, Department of Clinical Neuroscience, Karolinska Institutet, Huddinge, Sweden.
Scand J Psychol. 2013 Apr;54(2):66-71. doi: 10.1111/sjop.12023. Epub 2013 Jan 15.
Characterizing the anatomical substrates of major brain functions such as cognition and emotion is of utmost importance to the ongoing efforts of understanding the nature of psychiatric ailments and their potential treatment. The aim of our study was to investigate how the brain handles affective and cognitive interferences on cognitive processes. Functional magnetic resonance imaging investigation was performed on healthy individuals, comparing the brain oxygenation level dependent activation patterns during affective and cognitive counting Stroop tasks. The affective Stroop task activated rostral parts of medial prefrontal cortex (PFC) and rostral and ventral parts of lateral PFC, while cognitive Stroop activated caudal parts of medial PFC and caudal and dorsal parts of lateral PFC. Our findings suggest that the brain may handle affective and cognitive interference on cognitive processes differentially, with affective interference preferentially activating rostral and ventral PFC networks and cognitive interference activating caudal and dorsal PFC networks.
描述认知和情感等主要大脑功能的解剖学基础对于理解精神疾病的本质及其潜在治疗方法的持续努力至关重要。我们的研究旨在探讨大脑如何处理认知过程中的情感和认知干扰。对健康个体进行了功能磁共振成像研究，比较了情感和认知计数斯特鲁普任务期间大脑氧合水平依赖性激活模式。情感斯特鲁普任务激活了内侧前额叶皮质（PFC）的前颅部分和外侧 PFC 的前颅和腹侧部分，而认知斯特鲁普任务则激活了内侧 PFC 的后颅部分和外侧 PFC 的后颅和背侧部分。我们的研究结果表明，大脑可能会以不同的方式处理认知过程中的情感和认知干扰，情感干扰优先激活前颅和腹侧 PFC 网络，而认知干扰则激活后颅和背侧 PFC 网络。
