Bradfield Laura A, Balleine Bernard W
Behavioural Neuroscience Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia.
J Exp Psychol Anim Behav Process. 2013 Jan;39(1):2-13. doi: 10.1037/a0030941.
In two experiments we investigated the role of hierarchical S-(R-O) associations, as opposed to associative alternatives, in solving biconditional discrimination problems in rats. Using lesions of posterior dorsomedial striatum known to attenuate R-O associative learning, and lesions of the dorsolateral striatum that attenuate S-R learning, we found that whereas the lesions affecting R-O learning abolished biconditional discrimination, lesions of dorsolateral striatum did not (Experiment 1). Furthermore, in Experiment 2, we found, using a more challenging discrimination protocol, that dorsolateral striatal lesions actually enhanced biconditional discrimination learning. These results provide evidence that hierarchical S-(R-O) associations influence instrumental discrimination learning and compete with S-R associations for control of performance.
在两项实验中，我们研究了分层的S-(R-O)关联（与联想替代物相对）在大鼠解决双条件辨别问题中的作用。利用已知会减弱R-O联想学习的后内侧背侧纹状体损伤，以及会减弱S-R学习的背外侧纹状体损伤，我们发现，影响R-O学习的损伤消除了双条件辨别，而背外侧纹状体损伤则没有（实验1）。此外，在实验2中，我们使用更具挑战性的辨别方案发现，背外侧纹状体损伤实际上增强了双条件辨别学习。这些结果证明，分层的S-(R-O)关联会影响工具性辨别学习，并与S-R关联竞争对行为表现的控制。
