Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo 01246-904, Brazil.
Int J Food Sci Nutr. 2013 Aug;64(5):561-9. doi: 10.3109/09637486.2012.759188. Epub 2013 Jan 15.
This study investigated the effects of mate tea (Ilex paraguariensis) aqueous extract consumption on metabolic indicators and inflammatory response of peritoneal macrophages in rats fed a high-fat diet (HFD). Male Wistar rats were fed a control diet or a HFD for 12 weeks. At the end of this period, rats received, or not, daily doses of yerba maté for 4 weeks. The consumption of yerba maté promoted weight loss, attenuated the HFD-detrimental effects on adiposity and insulin sensitivity and decreased blood levels of the inflammatory biomarkers (p < 0.05). Concerning peritoneal macrophages, mate tea consumption decreased the production of interleukin (IL)-6, but did not influence the production of IL-1β, tumour necrosis factor-α and nitric oxide; cytokine mRNA expression; or the activation of the nuclear factor-κB signalling pathway. In summary, the consumption of mate tea had no consistent effect in the inflammatory response of peritoneal macrophages, but reduced cardiometabolic risk markers.
这项研究调查了马黛茶（Ilex paraguariensis）水提取物对高脂肪饮食（HFD）喂养大鼠代谢指标和腹腔巨噬细胞炎症反应的影响。雄性 Wistar 大鼠喂食对照饮食或 HFD 12 周。在此期间结束时，大鼠接受或不接受马黛茶的每日剂量 4 周。马黛茶的消耗促进了体重减轻，减轻了 HFD 对肥胖和胰岛素敏感性的不利影响，并降低了炎症生物标志物的血液水平（p < 0.05）。关于腹腔巨噬细胞，马黛茶的消耗减少了白细胞介素（IL）-6 的产生，但不影响白细胞介素（IL）-1β、肿瘤坏死因子-α和一氧化氮的产生；细胞因子 mRNA 表达；或核因子-κB 信号通路的激活。总之，马黛茶的消耗对腹腔巨噬细胞的炎症反应没有一致的影响，但降低了心血管代谢风险标志物。
