Hamdani Nissar Hussain, Qadri Sumyra Khurshid, Aggarwalla Ramesh, Bhartia Vishnu Kumar, Chaudhuri Sumit, Debakshi Sanjay, Baig Sarfaraz Jalil, Pal N K
Department of Surgical Gastroenterology, The Calcutta Medical Research Institute, Kolkata, India.
Asian Pac J Cancer Prev. 2012;13(11):5613-7. doi: 10.7314/apjcp.2012.13.11.5613.
Gallbladder carcinoma (GBC) is the commonest cancer of the biliary tree and the most frequent cause of death from biliary malignancies. The incidence of GBC shows prominent geographic, age, race, and gender-related differences and is 4-7 times higher in patients with gallstones. This prompted us to study the clinicopathological aspects of the disease and the incidence of gallstones in gallbladder carcinoma patients, in this part of India. In this, combined retrospective (Jan 2004-March 2010) and prospective study (April 2010-Dec 2011) of eight years, 198 patients of gallbladder carcinoma (50 males and 148 females), (range 28-82 years; mean 55 years) were studied. Most of the patients were poor and presented with abdominal pain and mass, with abnormal lab parameters. Gallstones were present in 86% of patients. Surgical exploration was performed in 130, with gallbladder resection in 60 (including 7 incidental GBC). Adenocarcinoma (87.7%) was the commonest histological type. The study indicates that GBC is common in our scenario. It is a disease of elderly females, has a strong association with gallstones and every cholecystectomy specimen should be examined histopathologically.
胆囊癌（GBC）是胆管树最常见的癌症，也是胆道恶性肿瘤最常见的死亡原因。GBC的发病率存在显著的地理、年龄、种族和性别差异，在胆结石患者中发病率高4至7倍。这促使我们研究印度该地区胆囊癌患者的疾病临床病理特征以及胆结石的发病率。在这项为期八年的回顾性（2004年1月至2010年3月）和前瞻性研究（2010年4月至2011年12月）中，对198例胆囊癌患者（50例男性和148例女性）（年龄范围28至82岁；平均55岁）进行了研究。大多数患者贫困，表现为腹痛和肿块，伴有实验室参数异常。86%的患者存在胆结石。130例患者进行了手术探查，60例进行了胆囊切除术（包括7例意外发现的GBC）。腺癌（87.7%）是最常见的组织学类型。该研究表明，在我们的研究场景中GBC很常见。它是老年女性的疾病，与胆结石密切相关，每个胆囊切除标本都应进行组织病理学检查。
