Bhattacharjee Prosanta Kumar, Nanda Durgaprasad
Department of Surgery, IPGMER/SSKM Hospital, Kolkata, West Bengal, India.
Department of Surgery, IPGMER/SSKM Hospital; Department of Surgical Oncology, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India.
J Cancer Res Ther. 2019 Jan-Mar;15(1):153-156. doi: 10.4103/jcrt.JCRT_939_17.
Gallbladder carcinoma (GBCA) is the fifth most common types of gastrointestinal malignancy and is the most common malignancy of the biliary tract. Cholelithiasis, gallbladder polyps, porcelain gall, and choledochal cysts are common known associations with GBCA. Because of the better understanding of the etiopathogenesis, the traditional nihilistic attitude toward the prognosis has, over the years, given way to greater interest and hope for treating the disease. Long-term survival has been reported in patients with resectable lesions in the hands of expert hepatobiliary surgeons.
This prospective observational study was conducted at a tertiary referral hospital of Eastern India on patients with the diagnosis of GBCA. The main objective was to assess the incidence of gallstones in patients with GBCA, and the relationship, if any, between the size and number of stones and GBCA in our patient cohort.
This prospective observational study was conducted, over a period of 2 years, at a tertiary referral hospital of Eastern India which caters to patients from all the neighboring districts. A total of 54 patients with the diagnosis of GBCA were included in the study. Data on their demographic and clinical profile, the incidence of associated gallstones, their size (<3 or ≥3cm), and number (solitary or multiple) were collected. Known predisposing factors of GBCA, if any, in those presenting without stones were noted.
GBCA was found to afflict females 2.4 times as frequently as males. Patients, irrespective of their sex, were mostly in their sixth decade. Approximately three-fourth of the cases had associated cholelithiasis. The number of stones had no correlation with the disease. However, contrary to available published data, stones <3 cm were significantly more common in our study cohort.
The results of this study reaffirm that cholelithiasis is a strong predisposing factor for GBCA and females with gallstones in their sixth decade, are more at risk. Although number of stones was not found to be an independent risk factor, patients with stones <3 cm (mostly multiple) were found to be more at risk in our study.
胆囊癌（GBCA）是第五大常见的胃肠道恶性肿瘤，也是最常见的胆道恶性肿瘤。胆结石、胆囊息肉、瓷胆囊和胆总管囊肿是已知的与胆囊癌相关的常见因素。由于对病因发病机制有了更好的理解，多年来，对预后的传统消极态度已逐渐被对治疗该疾病的更大兴趣和希望所取代。据报道，在经验丰富的肝胆外科医生手中，可切除病变患者能实现长期生存。
这项前瞻性观察研究在印度东部的一家三级转诊医院对诊断为胆囊癌的患者进行。主要目的是评估胆囊癌患者中胆结石的发病率，以及我们患者队列中结石大小和数量与胆囊癌之间的关系（若有）。
这项前瞻性观察研究在印度东部的一家三级转诊医院进行，为期2年，该医院接待来自所有邻近地区的患者。共有54例诊断为胆囊癌的患者纳入研究。收集了他们的人口统计学和临床资料、相关胆结石的发病率、结石大小（<3厘米或≥3厘米）和数量（单发或多发）。记录了那些无结石患者中已知的胆囊癌易感因素（若有）。
发现胆囊癌折磨女性的频率是男性的2.4倍。无论性别如何，患者大多处于第六个十年。大约四分之三的病例伴有胆结石。结石数量与疾病无相关性。然而，与现有已发表数据相反，在我们的研究队列中，<3厘米的结石明显更常见。
本研究结果再次证实，胆结石是胆囊癌的一个重要易感因素，第六个十年患有胆结石的女性风险更高。虽然结石数量未被发现是一个独立的危险因素，但在我们的研究中，<3厘米的结石患者（大多为多发）被发现风险更高。
