Mohebbipour Alireza, Saleh Parviz, Goldust Mohamad, Amirnia Mehdi, Zadeh Yousef Javad, Mohamadi Ramin Mir, Rezaee Elham
Department of Dermatology, Islamic Azad university, Tabriz, Iran.
Acta Dermatovenerol Croat. 2012;20(4):251-5.
Topical antiscabietics have poor compliance. This study aimed at comparing the efficacy and safety of oral ivermectin with topical lindane in treating scabies. In this clinical trial, 248 patients from 2 to 86 years of age were divided into two groups. Oral ivermectin was given to group A in a single dose of 200 μg/kg body weight. Group B received application of lindane lotion 1% twice at one-week interval. When there was no cure in two weeks, 2nd treatment was given with either drug in the respective group. A single dose of ivermectin provided a cure rate of 58.6% at two-week follow up, which increased to 92.7% with 2 doses at the end of 4-week interval. The application of lindane lotion 1% twice at one-week interval was effective in 44.3% of patients at two-week follow up, which increased to 71.7% after repeating the treatment for another two weeks. Single dose application of oral ivermectin was as effective as twice application of lindane lotion 1% at one-week interval. Two doses of ivermectin proved superior to lindane lotion 1% after repeating the treatment at 4-week follow up.
外用抗疥疮药的依从性较差。本研究旨在比较口服伊维菌素与外用林丹治疗疥疮的疗效和安全性。在这项临床试验中，248名年龄在2至86岁之间的患者被分为两组。A组口服单剂量200μg/kg体重的伊维菌素。B组接受1%林丹洗剂治疗，每周间隔使用两次。若两周内未治愈，则在各自组中使用相应药物进行第二次治疗。单剂量伊维菌素在两周随访时的治愈率为58.6%，在4周间隔结束时使用两剂后治愈率提高到92.7%。1%林丹洗剂每周间隔使用两次，在两周随访时44.3%的患者有效，再重复治疗两周后有效率提高到71.7%。口服单剂量伊维菌素与1%林丹洗剂每周间隔使用两次的效果相同。在4周随访重复治疗后，两剂伊维菌素被证明优于1%林丹洗剂。
