Department of Chemistry, University of Texas at San Antonio, San Antonio, Texas 78249, USA.
Org Lett. 2013 Feb 1;15(3):554-7. doi: 10.1021/ol303371u. Epub 2013 Jan 14.
Novel chiral binfunctional reagents V and ent-V undergo asymmetric aldehyde allylation followed by Ir(I)-catalyzed enantioselective allylic amidation to give orthogonally protected syn- and anti-1,3-aminoalcohols with complete control of absolute and relative stereochemistry. The Mitsunobu reaction of the initial homoallylic alcohol products followed by Ir(I)-catalyzed enantioselective allylic amidation provides orthogonally protected syn- and anti-1,3-diamine derivatives in high yields and with excellent stereoselectivities.
新型手性双功能试剂 V 和 ent-V 经历不对称醛烯丙基化反应，随后进行 Ir(I)催化的对映选择性烯丙基酰胺化反应，以高收率和优异的对映选择性得到完全控制绝对和相对立体化学的对位保护的顺式和反式 1,3-氨基醇。初始偕丙醇产物的 Mitsunobu 反应，随后进行 Ir(I)催化的对映选择性烯丙基酰胺化反应，以高产率和优异的对映选择性提供对位保护的顺式和反式 1,3-二胺衍生物。
