Department of Infectious Diseases and Gastroenterology, Key Laboratory of Paediatrics in Chongqing, Chongqing International Science and Technology Cooperation Centre for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Int J Tuberc Lung Dis. 2013 Feb;17(2):243-5. doi: 10.5588/ijtld.12.0777.
Genotyping that differentiates between strains of Mycobacterium tuberculosis based on variations in the genome of the organism is a useful tool for molecular epidemiological studies of tuberculosis. In the present study, we identified a combination of five mycobacterial interspersed repetitive unit (MIRU) loci and three variable numbers of tandem repeats (VNTR) loci of M. tuberculosis that showed a discriminatory power comparable to that of the 15 to 24 loci-based typing proposed for international standardisation in analysing 210 paediatric isolates obtained from Chongqing, China.
基于该生物体基因组差异进行结核分枝杆菌菌株分型的基因分型是结核分子流行病学研究的有用工具。在本研究中，我们鉴定了结核分枝杆菌的 5 个种间散布重复单位（MIRU）和 3 个可变数目的串联重复（VNTR）位点的组合，该组合在分析来自中国重庆的 210 例儿科分离株时显示出与国际标准化建议的基于 15 至 24 个位点的分型相当的区分能力。
Zotero 插件