Brunner J E, Johnson C C, Zafar S, Peterson E L, Brunner J F, Mellinger R C
Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan.
Clin Endocrinol (Oxf). 1990 Jan;32(1):65-71. doi: 10.1111/j.1365-2265.1990.tb03751.x.
A cohort of 52 subjects diagnosed with acromegaly in southeastern Michigan and northern Ohio between 1935 and 1985 were followed to determine the incidence of colon cancer and polyps. Medical records were reviewed, subjects or their next-of-kin were interviewed, and screening examinations of the colon were offered to the living patients who were located. Data on demographics, personal histories of cancer and colon polyps, family history of colon cancer, and cure from acromegaly were obtained for both living and deceased subjects. The risk for colon cancer compared to the general population was estimated using standardized incidence ratios (SIRs). The expected number of cases was determined utilizing age, sex and race-specific rates provided by the cancer registry in southeastern Michigan. Among the 52 subjects, one could not be located and nine were deceased, none from colon cancer, with one known to have a history of colon polyps. Of 13 (31%) who declined the screening physical, one had a history of polyps and none reported a history of colon cancer. Two of 29 screened patients were found to have right-sided adenocarcinoma of the colon. Of the entire cohort, eight people (including one deceased) had a current or previous diagnosis of polyps, with five known to be histologically adenomatous. The SIR for colon cancer was 4.7 (95% confidence interval 0.6-17.1). Seven subjects, including the two with detected adenocarcinoma and four of the six living subjects with polyps only, reported a family history of colon cancer. The SIR for the subset of subjects with a family history of colon cancer was 29.1 (95% confidence interval of 3.5-104.6).(ABSTRACT TRUNCATED AT 250 WORDS)
1935年至1985年间，在密歇根州东南部和俄亥俄州北部确诊为肢端肥大症的52名受试者被随访，以确定结肠癌和息肉的发病率。查阅了医疗记录，对受试者或其近亲进行了访谈，并为找到的在世患者提供了结肠筛查检查。获取了在世和已故受试者的人口统计学数据、癌症和结肠息肉个人病史、结肠癌家族史以及肢端肥大症治愈情况的数据。使用标准化发病率比（SIR）估计与普通人群相比患结肠癌的风险。预期病例数根据密歇根州东南部癌症登记处提供的年龄、性别和种族特异性发病率确定。在这52名受试者中，有1人无法找到，9人已故，均非死于结肠癌，其中1人已知有结肠息肉病史。在拒绝筛查体检的13人（31%）中，1人有息肉病史，无人报告有结肠癌病史。在29名接受筛查的患者中，有2人被发现患有右侧结肠癌。在整个队列中，8人（包括1名已故者）目前或既往被诊断为息肉，其中5人经组织学检查为腺瘤性。结肠癌的SIR为4.7（95%置信区间0.6-17.1）。7名受试者，包括2名检测到腺癌的患者和6名仅患有息肉的在世受试者中的4人，报告有结肠癌家族史。有结肠癌家族史的受试者亚组的SIR为29.1（95%置信区间3.5-104.6）。（摘要截短至250字）
