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[一例甲状腺功能减退症合并低钾性周期性麻痹]

[A case of hypothyroidism associated with hypokalemic periodic paralysis].

作者信息

Kinoshita I, Usa T, Satoh A, Tsujihata M

机构信息

First Department of Internal Medicine, Nagasaki University School of Medicine.

出版信息

Rinsho Shinkeigaku. 1990 Jan;30(1):100-2.

PMID:2331814
Abstract

A case of hypothyroidism associated with hypokalemic periodic paralysis was reported. The patient, a 50 year-old female was admitted because of recurrent paralytic attacks. She had not presented any symptoms of hypothyroidism. Physical examination on admission revealed muscle weakness of limbs, but not enlargement of thyroid glands. Paralytic attack was induced by oral intake of 100 g of glucose, and during attacks, serum K levels ranged from 3.4 to 3.0 mEq/l. She was diagnosed chronic thyroiditis by the high level of TSH and thyroid related anti-antibodies in the serum. Muscle biopsy showed type II atrophy. After the improvement of thyroid function, her paralytic attack disappeared. Present study suggested that hypothyroidism could be a cause of hypokalemic periodic paralysis. This case was very rare and seemed important in etiology of periodic paralysis.

摘要

报告了一例甲状腺功能减退症合并低钾性周期性麻痹的病例。该患者为一名50岁女性,因反复出现麻痹发作入院。她之前未出现任何甲状腺功能减退的症状。入院时体格检查发现四肢肌肉无力,但甲状腺未肿大。口服100克葡萄糖诱发了麻痹发作,发作期间血清钾水平在3.4至3.0毫当量/升之间。通过血清中促甲状腺激素(TSH)和甲状腺相关自身抗体水平升高,诊断为慢性甲状腺炎。肌肉活检显示Ⅱ型萎缩。甲状腺功能改善后,她的麻痹发作消失。目前的研究表明,甲状腺功能减退症可能是低钾性周期性麻痹的一个病因。该病例非常罕见,在周期性麻痹的病因学中似乎很重要。

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