Laboratory of Parasitic Diseases, Department of Veterinary Medicine, Federal University of Paraná, Curitiba, PR, Brazil.
Vet Parasitol. 2013 May 1;194(1):35-9. doi: 10.1016/j.vetpar.2012.12.020. Epub 2012 Dec 20.
The increase of anthelmintic resistance in the last years in the nematode population of veterinary importance has become a major concern. The objective of the present study was to evaluate the efficacy of the main anthelmintic drugs available in the market against small strongyles of horses in Brazil. A total of 498 horses from 11 horse farms, located in the states of Paraná, São Paulo, Rio de Janeiro and Minas Gerais, in Brazil, were treated with ivermectin, moxidectin, pyrantel and fenbendazole, orally at their recommended doses. The fecal egg count reduction test (FECRT) was used to determine the product's efficacy and fecal culture was used to determine the parasite genus. Reduction on anthelmintic efficacy was found for fenbendazole in all horse farms (11/11), pyrantel in five yards (5/11) and ivermectin had low efficacy in one of the yards studied (1/11). Multidrug resistance of up to 3 drugs classes was found in one of the tested farms (1/11). Cyathostomin were the most prevalent parasite. The results showed that resistance to fenbendazole is widespread; the efficacy of pyrantel is in a critical situation. Although the macrocyclic lactones compounds still showed high efficacy on most farms, suspected resistance to macrocyclic lactones is of great concern.
近年来，兽医重要线虫种群中驱虫剂耐药性的增加已成为一个主要关注点。本研究的目的是评估市场上主要驱虫药物对巴西马属小型圆线虫的疗效。总共对来自巴西巴拉那州、圣保罗州、里约热内卢州和米纳斯吉拉斯州的 11 个马场的 498 匹马使用伊维菌素、莫昔克丁、苯并咪唑和芬苯达唑进行治疗，按推荐剂量口服。粪卵计数减少试验（FECRT）用于确定产品的疗效，粪便培养用于确定寄生虫属。在所有的马场（11/11）中发现了苯并咪唑驱虫效果降低，在五个马场（5/11）中发现了吡喹酮驱虫效果降低，在研究的一个马场（1/11）中发现了伊维菌素的驱虫效果较低。在一个受测试的农场中发现了多达 3 种药物类别的多药耐药性（1/11）。Cyathostomin 是最普遍的寄生虫。结果表明，苯并咪唑耐药性广泛存在；吡喹酮的疗效处于危急状态。尽管大环内酯类化合物在大多数农场仍然表现出很高的疗效，但对大环内酯类化合物的疑似耐药性令人担忧。
